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PRODID:https://murmitoyen.com/events/vanille/udem/
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BEGIN:VEVENT
UID:69d98ce77ec42
DTSTAMP:20260410T195103
DTSTART:20190531T120000
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TRANSP:OPAQUE
DTEND:20190531T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/873670-guiding-synapt
 ic-plasticity-a-novel-role-for-the-chemotropic-guidance-cue-netrin-1-in-me
 mory-formation
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Guiding synaptic plasticity: a novel role for the chemotropic guida
 nce cue netrin-1 in memory formation
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nTitre complet de la conférence:
\nGuiding synaptic plasticity: a 
 novel role for the chemotropic guidance cue netrin-1 in memory formatio   
 Conférencier:Stephen Douglas Glasgow\, PhD\, Associé de recherche\, Inst
 itut neurologique de Montréal\, Université McGill
\nRésumé:Dynamic tra
 fficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamat
 e receptors (AMPARs) to excitatory synapses is critical for activity-depen
 dent synaptic plasticity underlying learning and memory\, however the iden
 tity of key molecular effectors remains elusive.
\nIn this talk\, I will d
 escribe recent evidence that suggests a novel role for the chemotropic gui
 dance cue\, netrin-1\, in synaptic transmission and plasticity. Originally
  described as a critical regulator of axon guidance in the developing nerv
 ous system\, we have found that netrin-1 continues to be expressed in the 
 adult brain and is localized to dendritic spines. Netrin-1 is released fro
 m dendrites following either neuronal depolarization or N-methyl-D-asparta
 te glutamate receptor (NMDAR) activation\, indicating that release of netr
 in-1 is dependent on neuronal activity. Selective genetic deletion of netr
 in-1 from excitatory neurons impairs NMDAR-dependent long-term potentiatio
 n (LTP) of excitatory synaptic responses in the adult hippocampus\, an exp
 erimental cellular model of learning and memory\, and results in significa
 nt impairments on spatial memory tasks. Moreover\, exogenous netrin-1 is s
 ufficient to trigger a long-lasting potentiation of excitatory glutamaterg
 ic transmission at hippocampal Schaffer collateral synapses that is mediat
 ed by Ca2+-dependent recruitment of GluA1-containing AMPARs\, as well as p
 romote the maturation of nascent synapses through regulation of dendritic 
 spine morphology. These findings identify a central role for activity-depe
 ndent release of netrin-1 as a critical effector of synaptic plasticity in
  the adult hippocampus\, and suggest that chemotropic guidance cues may pl
 ay key roles in synaptic modification underlying learning and memory proce
 sses.
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