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URL:https://murmitoyen.com/events/vanille/udem/detail/866680-conference-de-
 chimie-avec-le-professeur-daniel-g-riverauniversity-of-havana-havana-cub
LOCATION:Pavillon Roger Gaudry – Université de Montréal\, Montréal\, Q
 C\, Canada
SUMMARY:Conférence de chimie avec le Professeur Daniel G. Rivera\,Universi
 ty of Havana Havana\, Cub
DESCRIPTION:Titre : Multicomponent Reactions in Macrocyclization and Bioco
 njugation Chemistry
\n 
\nEndroit: Pavillon Roger-Gaudry\, Salle N-515
\n
  
\nHôte: William Lubell
\n 
\nRésumé : Multicomponent reactions hav
 e lately evolved from versatile methods for the synthesis of small molecul
 es to powerful tools for the post-synthetic derivatization of peptides1 an
 d proteins.2 This lecture highlights the most recent multicomponent transf
 ormations conducted at UH and IPB to covalently modify peptides and protei
 ns. These transformations include the multicomponent labeling and stapling
  of peptides by means of the Petasis reaction as well as the utilization o
 f the Ugi and Ugi-Smiles multicomponent reactions for the simultaneous lip
 idation/PEGylation and cyclization of peptides.3 Finally\, our recent ende
 avor on the development of antibacterial glycoconjugate vaccine candidates
  by means of a multicomponent polysaccharide-protein conjugation is descri
 bed.2 (Voir PDF)
\n 
\n1 (a) C. J. White\, A. K. Yudin\, Nature Chem. 2011
 \, 3\, 509. (b) A. V. Vasco\, C. S. Pérez\, F. E. Morales\, H. E. Garay\,
  D. Vasilev\, J. A. Gavín\, L. A. Wessjohann\, D. G. Rivera\, J. Org. Che
 m. 2015\, 80\, 6697.
\n2  Y. Méndez\, J. Chang\, A. R. Humpierre\, A. Za
 nuy\, R. Garrido\, A. V. Vasco\, J. Pedroso\, D. Santana\, L. M. Rodrígue
 z\, D. García-Rivera\, Y. Valdés\, V. Vérez-Bencomo\, D. G. Rivera\, Ch
 em. Sci. 2018\, 9\, 2581.
\n3   (a) M. C. Morejón\, A. Laub\, G. N. Kal
 uđerović\, A. R. Puentes\, A. N. Hmedat\, A. J.\; Otero-González\, D. G
 . Rivera\, L. A. Wessjohann\, Org. Biomol. Chem. 2017\, 15\, 3628. (b) M. 
 C. Morejón\, A. Laub\, B. Westermann\, D. G. Rivera\, L. A. Wessjohann\, 
 Org. Lett. 2016\, 18\, 4096
\nPDF de la conférence
\n 
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