BEGIN:VCALENDAR
VERSION:2.0
PRODID:https://murmitoyen.com/events/vanille/udem/
X-WR-TIMEZONE:America/Montreal
BEGIN:VEVENT
UID:69d9c5f18f4b7
DTSTAMP:20260410T235425
DTSTART:20190327T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20190327T110000
URL:https://murmitoyen.com/events/vanille/udem/detail/851508-conference-de-
 chimie-avec-le-professeur-mark-crimmin-imperial-college-london-uk
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence de chimie avec le Professeur Mark Crimmin\, Imperial Co
 llege\, London\, UK
DESCRIPTION:Titre: ''Unusual Regiocontrol in the Carbon–Hydrogen Bon
 d Activation with Intermetallic Catalysts''   Emdroit: Pavillon Roger-Ga
 udry\, Salle G-815   Hôte: Davit Zargarian   Résumé: 'Once unimagina
 ble\, catalytic methods that selectively break C–H bonds in organic mole
 cules are now considered indispensable in synthesis. The activation and fu
 nctionalisation of inert C–H bonds in hydrocarbons from oil refineries\,
  such as benzene\, toluene and xylenes\, is arguably one of the most chall
 enging facets of this field.1-2 We recently discovered some unusual Pd–A
 l intermetallic complexes capable of breaking the C–H bond of benzene at
  25 oC.3 Here we present the catalytic C–H alumination of benzene\, tolu
 ene and xylenes using both Al(I) and Al(III) dihydride reagents. (Voir PDF
 ). Remarkably these reactions proceed primarily with ortho- and meta-selec
 tivity\, indicative of a new mode of regiocontrol that is complementary to
  both C–H borylation and Friedel-Crafts methodology (Figure – b). Prel
 iminary mechanistic analysis suggests that C–H activation is the rate-li
 miting and selectivity determining step and that weak dispersion forces be
 tween the ligands and substrate determine the regiochemistry of C–H func
 tionalisation. 
\n1. Labinger\, J. A.\; Bercaw\, J. E.\, Nature 2002\, 417
 \, 507. 2.Bergman\, R. G.\, Nature 2007\, 446\, 391. 3. Discovered during 
 mechanistic studies that resulted from: Chen\, W.\; Hooper\, T. N.\; Ng\, 
 J.\; White\, A. J. P.\; Crimmin\, M. R. Angew. Chem.\, Int. Ed. 2017\, 56\
 , 12687. '
\nPDF de la conférence
END:VEVENT
BEGIN:VTIMEZONE
TZID:America/Montreal
X-LIC-LOCATION:America/Montreal
END:VTIMEZONE
END:VCALENDAR