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PRODID:https://murmitoyen.com/events/vanille/udem/
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UID:69da58aca6569
DTSTAMP:20260411T102028
DTSTART:20181026T120000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20181026T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/842321-zebrafish-a-sy
 nchrotron-and-a-3d-printer-unlikely-allies-in-understanding-diagnosing-and
 -treating-osteoarthritis
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Zebrafish\, a synchrotron\, and a 3D printer: Unlikely allies in un
 derstanding\, diagnosing\, and treating osteoarthritis
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nTitre complet :Zebrafish\, a synchrotron\, and a 3D printer: Unlik
 ely allies in understanding\, diagnosing\, and treating osteoarthritis
\nC
 onférence de Brian F. Eames\, PhD\, professeur agrégé\, Département d
 'anatomie\, de physiologie et de pharmacologie\, Université de la Saskatc
 hewan
\nRésumé :Osteoarthritis (OA) affects the skeletal joints of over 
 10% of all Canadians\, with up to 50% of the elderly afflicted.  Despite 
 this significant health burden\, the understood causes and treatment optio
 ns for OA are relatively limited. In this talk\, I highlight the variety o
 f approaches in my lab that aim to shed light on these health issues. Usin
 g zebrafish developmental genetics\, we identify and characterize novel pl
 ayers in the proteoglycan synthesis pathway to help understand the molecul
 ar mechanisms of OA\, also analyzing the role of proteoglycan-dependent gr
 owth factor signalling. Using novel synchrotron imaging techniques\, such 
 as phase-contrast micro-CT and X-ray fluorescence\, we help develop diagno
 stic tools for OA\, taking advantage of cartilage proteoglycan sulfation. 
 Finally\, we use a hybrid\, 3D bioprinting approach to mimic both the mech
 anical and biological properties of articular cartilage\, helping to provi
 de a novel therapeutic treatment for sufferers of OA.
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