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PRODID:https://murmitoyen.com/events/vanille/udem/
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UID:69da43ca3572e
DTSTAMP:20260411T085122
DTSTART:20181005T120000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20181005T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/839241-from-point-mut
 ations-to-genome-scale-models-a-network-perspective
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:From Point Mutations to Genome-scale Models: A Network Perspective
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nConférence de Jasmin Coulombe-Huntington\, PhD\, stagiaire postdo
 ctoral\, Institut de recherche en immunologie et en cancérologie (IRIC)\,
  Université de Montréal.
\nRésumé :Genome-wide CRISPR/Cas9 knockout sc
 reens can reveal genotype-to-phenotype relationships and mechanisms of res
 istance and sensitization to drugs and other compounds. We have undertaken
  more than 250 CRISPR/Cas9 screens to map these relationships. I will pre
 sent a plan to apply network-based approaches to model fitness effects of 
 gene knockouts to predict drug mechanisms\, gene functions\, cancer-specif
 ic vulnerabilities and synergistic drug combinations.  I will also cover 
 earlier work on the network-level effects of alternative splicing and dise
 ase variants and present a machine learning-based strategy to reconstruct 
 signaling pathways mediated by short linear motifs in disordered protein r
 egions.
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