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UID:69da58dae2fee
DTSTAMP:20260411T102114
DTSTART:20180921T120000
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DTEND:20180921T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/837705-beyond-neurona
 l-migration-the-changing-roles-of-lis1-in-maturing-brain
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Beyond Neuronal Migration: the changing roles of LIS1 in maturing b
 rain
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine  Conférence de Margaret Elizabeth Ross\, MD\, PhD\, directrice du 
 Centre de neurogénétique\, Institut de recherche sur le cerveau et l'esp
 rit\, Weill Cornell Medicine\, New York\, NY
\nRésumé :Happloinsufficien
 cy of LIS1 causes a severe human brain malformation called lissencephaly. 
 Though structurally similar to Gbeta proteins\, the most intensively studi
 ed LIS1 function is its relationship with microtubules and its interaction
  with the minus end directed dynein protein motor and with dynein complex 
 proteins including NUDEL\, p150Glued dynactin subunit\, and CLIP170. In th
 is presentation we will discuss the impact of LIS1 on Rho family GTPase ac
 tivity and the actin based cytoskeleton as it relates not only to neuronal
  migration but also LIS1 roles once migration is over. These include NMDA 
 receptor signal transduction\, synaptogenesis\, neurite spine turnover and
  maintenance of neuronal connectivity and survival. These effects have pro
 found impact on behavior. A picture for LIS1 is emerging as a hub protein 
 that promotes optimal synaptic plasticity and excitatory-inhibitory balanc
 e with relevance for neuropsychiatric disorders including autism spectrum\
 , schizophrenia and dementia.
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