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PRODID:https://murmitoyen.com/events/vanille/udem/
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UID:69db154adc578
DTSTAMP:20260411T234514
DTSTART:20171219T150000
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TRANSP:OPAQUE
DTEND:20171219T160000
URL:https://murmitoyen.com/events/vanille/udem/detail/794769-epigenetic-rep
 rogramming-in-cancer
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Epigenetic Reprogramming in Cancer
DESCRIPTION:Conférence scientifique de l'Unité collaborative en épigén
 étique moléculaire (UCEM)
\nConférence de Mathieu Lupien\, PhD\, Assist
 ant Professor\, Department of Medical Biophysics\, Princess Margaret Cance
 r Centre/University Health Network University of Toronto.
\nRésumé :Canc
 er development is commonly ascribed to genetic alterations\, whether inher
 ited or acquired. These commonly promote epigenetic reprogramming to induc
 e transcriptional programs favorable to dedifferentiation and long-term se
 lf-renewal. However\, cancer can also arise independently of genetic alter
 ations. For instance\, pediatric ependymomas are free of recurrent genetic
  alterations. Yet\, they harbor epigenetic changes that drive tumor growth
 . In this presentation\, we will explore the intricate relationship betwee
 n genetic alterations and epigenetic reprogramming in prostate cancer and 
 present alternative mechanisms from our recent work in breast cancer that 
 supports epigenetic reprogramming independently of genetic alterations.
\n
 Pour de plus amples renseignements sur l'Unité collaborative en épigén
 étique moléculaire
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