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UID:69db6026387d1
DTSTAMP:20260412T050438
DTSTART:20171115T103000
SEQUENCE:0
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DTEND:20171115T103000
URL:https://murmitoyen.com/events/vanille/udem/detail/790412-targeted-coval
 ent-inhibition-of-transglutaminase-in-cancer-stem-cells
LOCATION:Pavillon Roger-Gaudry \, 2900\, boul. Édouard-Montpetit\, Local M
 -415\, Montréal\, QC\, Canada
SUMMARY:Targeted Covalent Inhibition of Transglutaminase in Cancer Stem Cel
 ls
DESCRIPTION:Conférence de chimie avec le professeur Jeffrey Keillor de l'U
 niversité d'Ottawa.
\nHôte : Joelle Pelletier
\nRésuméRecent evidence 
 has shown that tissue transglutaminase (TG2) is a key player in the metast
 atic progression of cancer. TG2 is an enzyme that was first identified for
  its ability to mediate the extracellular cross-linking of proteins throug
 h the formation of isopeptide bonds\; this transamidation reaction is cata
 lysed by the enzyme when it adopts an extended conformation. However\, TG2
  is also known to play a role as a GTP binding protein in intracellular G 
 protein signalling\, for which it adopts a dramatically more compact confo
 rmation. Most recently\, TG2 expression has been implicated in inducing th
 e epithelial-mesenchymal transition (EMT) in ovarian\, breast and epiderma
 l cancer stem cells\, contributing to their development of drug resistance
  and metastatic competence.
\nOver the past ~20 years of research into TG2
  mechanism and inhibition\, we have developed many reversible and irrevers
 ible inhibitors. Recent results will be presented\, where we have demonstr
 ated that our targeted covalent inhibitors are able to modulate the confor
 mation of TG2 and abolish both its transamidation and GTP-binding activiti
 es\, in vitro and in living human cells. Furthermore\, collaborative effor
 ts have shown that several of our inhibitors are able to halt the EMT of e
 pidermal cancer stem cells (CSCs)\, through a mechanism of action that inv
 olves perturbation of a specific signalling pathway critical to CSC surviv
 al.
\nWebsite:  Keillor-research-group.com 
\nTwitter account @theKeillo
 rsAnnonce PDF de la conférence
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