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UID:69db45e5a2923
DTSTAMP:20260412T031237
DTSTART:20171004T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20171004T110000
URL:https://murmitoyen.com/events/vanille/udem/detail/777897-conference-de-
 chimie-avec-le-professeur-mark-nitz-toronto
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence de chimie avec le Professeur Mark Nitz (Toronto)
DESCRIPTION:Titre : Tellurium in Biological Probes for Mass Cytometry—Tel
 l us MoreHôte : Professeure Joëlle PelletierEndroit: Pavillon J.-Armand 
 Bombardier\, local 1035 à partir de 11h
\nCette conférence sera pronon
 cée par le Professeur Mark Nitz de la University of Toronto.
\nRÉSUM
 É: Mass Cytometry (MC) offers unparalleled potential for the development 
 of highly parameterized cellular assays. Using antibody-metal chelating po
 lymer conjugates\, MC has made the simultaneous analysis of >40 biomarkers
  at the cellular level broadly available to the research community. To com
 pliment these bioaffinity reagents we are expanding the dimensions of MC a
 nalysis by developing small molecule probes designed for use with the tech
 nology. A compact MC-detectable fragment containing tellurium has been gen
 erated that can be conjugated to a variety of probes to target biological 
 processes such as enzyme activity\, metabolism or transport. In a key exam
 ple of the potential of this approach a series of tellurium containing iso
 topologous probes for cellular hypoxia were synthesized. Sequential labell
 ing with the isotopologous probes (SLIP) of pancreatic tumour xenograft mo
 dels revealed changes in cellular oxygenation over time which correlates w
 ith the distance from vasculature\, the proliferation of cell populations\
 , and proximity to necrosis. SLIP allows for capture of spatial and tempor
 al dynamics in vivo which can be deconvoluted in highly parametric experim
 ents by imaging MC. Using this approach for probe development we will desc
 ribe for following protein synthesis\, replicative senescence and glycopro
 tein synthesis by MC.
\n 
\nAnnonce PDF de la conférenceInformations sup
 plémentaires
\n 
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