BEGIN:VCALENDAR
VERSION:2.0
PRODID:https://murmitoyen.com/events/vanille/udem/
X-WR-TIMEZONE:America/Montreal
BEGIN:VEVENT
UID:69dbeedc2e29b
DTSTAMP:20260412T151332
DTSTART:20170306T113000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20170306T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/744247-gas-phase-drug
 -discovery-physicochemical-property-measurements-with-differential-mobilit
 y-spectrometry-w-scott-hopkins-waterloo
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Gas Phase Drug Discovery:  Physicochemical Property Measurements wi
 th Differential Mobility Spectrometry - W. Scott Hopkins (Waterloo)
DESCRIPTION:Gas Phase Drug Discovery: Physicochemical Property Measurement
 s with Differential Mobility Spectrometry
W. Scott Hopkins\, Chemistry Dep
 artment\, University of Waterloo
Abstract: 
In vitro measurements of phys
 icochemical properties such as pKa and cell permeability routinely serve a
 s a key step in a drug’s overall development pathway. However\, these me
 asurements can be time-consuming\, labor-intensive\, and low-resolution. R
 ecently\, in partnership with researchers SCIEX and Pfizer\, we have begun
  developing a physicochemical properties measurement technique which emplo
 ys differential mobility spectrometry (DMS). DMS is an analytical techniqu
 e that can separate isomers\, conformers\, and even tautomers based upon t
 heir different microsolvation propensities in a gas-phase environment. By 
 using DMS to assess the interaction strengths between drug molecules and s
 olvent vapor\, we have identified correlations between drug microsolvation
  and several condensed phase drug properties. Our measurements\, which can
  be conducted in seconds using only nanograms of sample\, and supporting e
 lectronic structure calculations provide insight regarding the subtle effe
 cts of geometric and electronic structure on in vitro drug properties. Our
  most recent results suggest that this DMS-based technique can potentially
  be used as a new\, high-throughput tool in rational drug design.
In this 
 seminar\, I will discuss our most recent results and provide a perspective
  for future directions in this research.
To know more about Prof. Hopkins'
  group\, see his web site.
Cette conférence est présentée par le RQMP
  Versant Nord du Département de physique de l'Université de Montréal
  et de Génie physique de la Polytechnique.
END:VEVENT
BEGIN:VTIMEZONE
TZID:America/Montreal
X-LIC-LOCATION:America/Montreal
END:VTIMEZONE
END:VCALENDAR