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UID:69dc07850aff3
DTSTAMP:20260412T165845
DTSTART:20170118T110000
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TRANSP:OPAQUE
DTEND:20170118T110000
URL:https://murmitoyen.com/events/vanille/udem/detail/735268-conference-du-
 professeur-david-schriemer-calgary
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence du Professeur David Schriemer (Calgary)
DESCRIPTION:Titre: Structural proteomics: a bioanalytical toolkit for model
 ing protein systems using mass spectrometry
\nEndroit : Pavillon J.-Armand
  Bombardier\, salle 1035 à 11 h
\nHôte : Pierre Thibault
\nCette conf
 érence sera prononcée (en alglais) par le Professeur David Schriemer
  du département de biochimie et biologie moléculaire de l'Université d
 e Calgary.
\nRÉSUMÉ: Integrative methods in structural biology use data 
 from various sources to generate accurate models of large multi-protein as
 semblies. The approach uses available protein structures as the “buildin
 g blocks” of a large assembly\, and combines them with biophysical data 
 collected on the assembly. If the data contain sufficient spatial informat
 ion\, molecular modeling can generate accurate models of the whole. In thi
 s way\, the classical techniques used in structure determination can reach
  beyond their current limitations. Accurate molecular models of impressive
  size and complexity can be generated that lead to new biological insights
 \, and new opportunities for drug development.
\nThe field of integrative 
 structure determination is still young\, and it lacks sufficiently rich so
 urces of biophysical data to constrain the model-building exercise. Mass s
 pectrometry (MS) has enormous potential to serve as a key provider of stru
 ctural restraints. Methods are emerging that provide information on protei
 n shape\, topography\, orientation and dynamics\, but significant analytic
 al and informatics challenges have limited MS to smaller systems. This pre
 sentation will describe our vision for structural proteomics\, and our pro
 gress towards generating a complete bioanalytical platform that supports a
 n MS-based structural analysis of ultra-large protein systems. Our strateg
 y involves coding protein structure into mass-readable signatures via chem
 ical labeling. We use photolytic reagents (for interface mapping)\, hydrog
 en/deuterium exchange (for protein dynamics) and crosslinking (for structu
 re and orientation). Using examples drawn from our research in mitotic reg
 ulation\, DNA damage repair and vaccine development\, I will highlight new
  methods for installing and measuring these structural codes that scale we
 ll to large protein systems. I will introduce a new software framework tha
 t we developed to support MS-driven structure-building activities (Mass Sp
 ec Studio\, www.msstudio.ca).
\nInformation supplémentaire 
\nAnnonce PDF
  de la conférence
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