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DTSTAMP:20260410T232716
DTSTART:20161202T100000
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URL:https://murmitoyen.com/events/vanille/udem/detail/734437-conference-doc
 teur-frantz-le-develec
LOCATION:Pavillon Roger-Gaudry \, 2900\, boul. Édouard-Montpetit\, Local M
 -415\, Montréal\, QC\, Canada
SUMMARY:Conférence Docteur Frantz Le Dévélec
DESCRIPTION:Titre :Post-Alkylation of a Common mPEG-b-PAGE Precursor to Pro
 duce Tunable Morphologies of Spheres\, Filomicelles\, Disks and Polymersom
 es for Applications in Drug DeliveryEndroit : Pavillon Roger-Gaudry\, sall
 e S-142 à 10 h.Hôte : Julian Zhu
\nLa conférence sera prononcée par
  Frantz Le Dévédec Ph.D.\, ancien étudiant du Groupe du Prof. Julian 
 Zhu.
\nRésumé : The facile preparation of biocompatible materials that s
 elf-assemble into nanostructures of well-defined morphology is of keen int
 erest to the biomedical community. The mPEG-b-PAGE copolymer was then used
  as a common precursor to generate a systematic series of copolymers deriv
 atized with pendant alkyl chains via thiolene click chemistry. Polyalkylat
 ed copolymers based on mPEG-b-(AGE-C6\,12 or 18)25 have been used to formu
 late clinically relevant concentrations of doxorubicin (DOX) and the impac
 t of drug incorporation on copolymer aggregation behaviour was examined. 
   The copolymer aggregates were analyzed by various microscopy techniques
  (TEM\, cryo-TEM and AFM) and scattering methods (SANS\, DLS). In the abse
 nce of drug\, the copolymers formed largely non-spherical aggregates (i.e.
  cylinders\, vesicles). DOX incorporation had a striking impact on the mor
 phology of the PCAs. As well\, the nature of the core-forming block was fo
 und to influence drug release and cytotoxicity of the formulations. The pr
 omising preliminary assessment of these alkylated copolymers encourages ad
 ditional evaluation in vivo.
\nAnnonce PDF de la conférence
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