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DTSTART:20160913T120000
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URL:https://murmitoyen.com/events/vanille/udem/detail/719240-global-tools-c
 onnecting-exposure-toxicokinetics-and-toxicity-in-food-safety-the-contribu
 tion-of-the-european-food-safety-authority
LOCATION:Université de Montréal - 7101 avenue du Parc\, 7101\, avenue du 
 Parc\, Montréal\, QC\, Canada\, H3N 1X9
SUMMARY:Global tools connecting exposure\, toxicokinetics and toxicity in f
 ood safety: the contribution of the European Food Safety Authority
DESCRIPTION:Séminaire de l'IRSPUM
\n 
\nTitre du séminaire
\n 
\nGlobal
  tools connecting exposure\, toxicokinetics and toxicity in food safety: t
 he contribution of the European Food Safety Authority
\n 
\nChemical risk
  assessment in the food safety area involves the classic steps bringing ha
 zard and exposure for risk characterisation. In the food safety area\, sou
 nd hazard identification and hazard characterisation requires an understan
 ding of both toxicokinetic (TK) and toxicodynamic (TD) processes for compo
 unds entering the human body via the oral route. This enables the translat
 ion of external dose (exposure) into internal dose TK processes incorporat
 ing absorption\, distribution\, metabolism\, excretion of chemicals (ADME)
  and toxicity for sound dose response modelling. Since its creation in 200
 2\, the European Food Safety Authority has published over 2000 risk assess
 ments for over 4000 substances in the human health\, animal health and the
  ecological areas. Openfoodtox: EFSA ‘s open source database which provi
 des summary hazard data for individual chemicals has been designed using O
 ECD harmonised templates and is briefly described (publicly available by D
 ec 2016). In addition\, the development of open source TK tools and models
  to further integrate exposure\, TK processes and toxicity in the human he
 alth\, animal health and ecological areas are outlined. Another challenge 
 is the harmonisation of human and ecological risk assessment of combined e
 xposure to multiple chemicals (“chemical mixtures”). A brief overview 
 of past\, present and future EFSA activities in this area is presented. Th
 e need to take into account international developments (e.g. OECD\, WHO\, 
 theUS-EPA\, the three non-food committees of the European Commission) is h
 ighlighted as critical for the harmonisation of methodologies. Future deve
 lopments of global risk assessment tools in the food safety area are discu
 ssed in the context of mechanistic alternatives to animal testing such as
  in silico and in vitro tools and tiered weight of evidence approaches
  tailored to support risk assessors in a practical way. International coop
 eration between national and international scientific advisory bodies and 
 academic institutions concludes as the corner stone for the translation of
  21st century toxicological research into harmonised methodologies and to
 ols and for the training of the next generation of risk assessors.
\n 
\n
 Conférencier
\n 
\nJean-Lou Dorne\, Senior Scientific Officer-Toxicolog
 ist\, Scientific Committee and Emerging Risks Unit\, Department of Risk A
 ssessment and Scientific Assistance\, European Food Safety Authority
\n 
 
\nSince 2006\, Dr Jean-Lou Dorne has been a senior scientific officer a
 t the European Food Safety Authority in the Scientific Committee and Emerg
 ing Risks Unit. After 9 years of research at the University of Southampton
  (UK). Dr Dorne received a DUT in applied biology (Lyon University)\, a BS
 c (Hons) in pharmacology (Coventry University)\, MSc Toxicology (of Surrey
  University)\, MSc Molecular Biology (Natural History Museum Paris) and a 
 Ph.D. Toxicology on human variability in toxicokinetics for the major meta
 bolic pathways: applications to chemical risk assessment (Southampton Univ
 ersity). His current work focuses on the development of harmonised methodo
 logies applied to human health\, animal health and ecological risk assessm
 ent of chemicals.
\n 
\n  
\n 
\nAnimateur 
\n 
\nMichèle Bouchard\
 , chercheuse\, IRSPUM et professeure titulaire\, Département de santé e
 nvironnementale et santé au travail\, ESPUM
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