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UID:69dc9f6f8875f
DTSTAMP:20260413T034655
DTSTART:20160916T134500
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20160916T144500
URL:https://murmitoyen.com/events/vanille/udem/detail/715786
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence Foncer- SFC avec le Professeur Joel Hawkins ( Pfizer)
DESCRIPTION:Titre : Flow Chemistry for Pharmaceutical SynthesisEndroit : Pa
 villon J.-Armand Bombardier\, salle 1035 à 13 h 45.Hôte : Vanessa Kair
 ouz
\nCette conférence sera prononcée (en anglais) par le Professeur 
 Joel Hawkins de Pfizer Global Research & Development. 
\nRésumé :
\nFlo
 w chemistry and continuous processing offer advantages for the synthesis a
 nd manufacture of active pharmaceutical ingredients (APIs) from chemistry\
 , engineering\, and business perspectives. These are exemplified by the sy
 nthesis of an H antagonist where excellent mixing\, stoichiometry control\
 , and heat3 removal increased the chemoselectivity of a tubo-Grignard addi
 tion\, and the synthesis of tafamidis where a flow oxidation route improve
 d the environmental or E-factor by tenfold relative to the original route.
  Additionally\, the development of flow hydrogenations using small particl
 e catalysts are described which improve the stereoselectivity\, chemoselec
 tivity\, and efficiency of the reduction of intermediates in API syntheses
  relative to batch hydrogenations. And lastly\, simple processes flowing t
 hrough metal oxide catalysts are described for efficient oxidations\, redu
 ctions\, and hydrolyses.
\n 
\nInformation supplémentaireAnnonce PDF de 
 la conférence
\n 
\n 
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