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DTSTAMP:20260413T051534
DTSTART:20160906T120000
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URL:https://murmitoyen.com/events/vanille/udem/detail/715564
LOCATION:Université de Montréal - Carrefour des arts et des sciences\, 31
 50\, rue Jean-Brillant \, Montréal\, QC\, Canada\, H3T 1N8
SUMMARY:Conférence de M. Ferran CASALS
DESCRIPTION:Titre : An assessment of a massively parallel sequencing approa
 ch for the identification of individuals from mass graves of the Spanish C
 ivil War (1936-1939)
Conférencier : Ferran Casals (Genomics Core Faciliy\
 , CEXS – Universitat Pompeu Fabra\, Barcelona)
His current research inte
 rest include the development and application of new experimental methodolo
 gies for genetic analyses\, the study of the genetic etiology of rare dise
 ases\, and the analysis of the genetic variation across human populations\
 , with particular interest in rare functional variants and its relation to
  disease prevalence. At the Genomics Core Facility we also develop collabo
 rative projects with other UPF laboratories\, covering a variety of applic
 ations of next-generation sequencing technologies to different research fi
 elds.
Résumé
Next generation sequencing technologies have opened new opp
 ortunities in forensic genetics. Here we assess the applicability and perf
 ormance of the MiSeq FGx™ & ForenSeq™ DNA Signature Prep Kit (Illumina
 ) to the identification of individuals from the mass graves of the Spanish
  Civil War (1936-1939). The main limitations for individual identification
  are the low number of possible first-degree living relatives and the high
  levels of DNA degradation reported in previous studies. Massively paralle
 l sequencing technologies enabling the analysis of hundreds of regions and
  prioritizing short length amplicons constitute a promising tool for this 
 kind of approaches. In this study\, we first explore the power of this new
  technology to detect first and second degree kinship given different scen
 arios of DNA degradation. Second\, we specifically assess its performance 
 in a set of low DNA input samples previously analyzed with capillary elect
 rophoresis technologies. We conclude that this methodology will allow iden
 tification of up to second-degree relatives\, even in situations with low 
 sequencing performance and important levels of allele drop-out\; it is thu
 s a technology that resolves previous drawbacks and that will allow a succ
 essful approximation to the identification of remains.
Information
Confér
 ence organisée conjointement par le Centre international de criminologie
  comparée et le département d'anthropologie.
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