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DTSTAMP:20260413T120756
DTSTART:20160205T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20160205T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/651940
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Séminaire de l'étudiant Alexander Cunningham (Groupe Zhu)
DESCRIPTION:Titre : Development of Bile Acid-Based Nanoparticles for Biomed
 ical Applications. Endroit : Pavillon Roger-Gaudry\, salle G-615 à 11 h 3
 0.
\nCette conférence sera prononcée (en anglais) par Monsieur Alexander
  Cunningham\, étudiant au doctorat\, du laboratoire de Julian Zhu\, prof
 esseur au Département de chimie de l'Université de Montréal.
\nRésumé
  : Over 40% of recently discovered therapeutic molecules are insoluble in 
 physiological conditions rendering them either ineffective or toxic. The u
 se of drug delivery nanocarriers enables the safe and efficient spatiotemp
 oral delivery of therapeutic molecules. Despite the breadth of research on
  the topic\, very few successful polymer-based drug delivery systems are c
 urrently on the market due to insufficient biocompatibility\, inefficient 
 drug encapsulation\, or unstable formulations. Bile acid-based amphiphilic
  block copolymers offer a promising solution. Bile acids are excellent can
 didates as starting materials in the design of biomaterials due to their n
 on-toxicity\, amphiphilic properties\, relative abundance in nature\, and 
 convenience of chemical modifications. Specifically\, using cholic acid as
  an initiator\, poly(ethylene glycol) and poly(allyl glycidyl ether) of va
 rious chain lengths were synthesized via anionic ring-opening polymerizati
 on to help in the flexibility and stability of the micelles for combined d
 rug and gene delivery directed towards anti-cancer treatment.
\nInformatio
 n supplémentaireAnnonce PDF du séminaire
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