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DTSTAMP:20260414T061403
DTSTART:20150831T110000
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URL:https://murmitoyen.com/events/vanille/udem/detail/624086
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Séminaire de l'étudiant Jeffrey Santandrea (Groupe Collins)
DESCRIPTION:Titre : Improved Catalysis for Macrocyclization Reactions.Endro
 it : Pavillon Roger-Gaudry\, salle G-615 exceptionnellement à 11 h.
\nCet
 te conférence sera prononcée (en anglais) par Monsieur Jeffrey Santandre
 a\, étudiant au doctorat\, du laboratoire de Shawn Collins\, professeur 
 au Département de chimie de l'Université de Montréal.
\nRésumé : Macr
 ocyclic products are usually synthesized from a handful of known macrocycl
 ization methods. Surprisingly\, the Sonogashira coupling has yet to be a c
 ommonly used method to accomplish macrocyclizations\, despite relatively m
 ild reaction conditions. However\, recent examples highlight the lack of p
 racticality and effectiveness of the reaction on a large scale\, since sig
 nificant amounts of palladium and stoichiometric amounts of copper in a di
 lute media are needed to afford benzolactones in poor yields. The developm
 ent of thermal and photochemical copper-catalyzed Sonogashira protocols pe
 rformed at high concentrations are described as alternatives to Pd-catalyz
 ed methods to access a wider range of compounds and pharmaceutically relev
 ant motifs such as polyketide-derived resorcyclic acid lactones.
\nInforma
 tion supplémentaireAnnonce PDF du séminaire
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