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DTSTAMP:20260414T183619
DTSTART:20150413T113000
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URL:https://murmitoyen.com/events/vanille/udem/detail/598784-design-and-mic
 rofabrication-of-micro-and-nanotools-for-biological-applications-n-margare
 t-magdesian-mcgill
LOCATION:Polytechnique Montréal - Pavillon J.-Armand-Bombardier\, 5155\, a
 venue Decelles\, Montréal\, QC\, Canada\, H3T 2B1
SUMMARY:Design and Microfabrication of Micro and Nanotools for Biological A
 pplications – Margaret Magdesian\, McGill
DESCRIPTION:Margaret Magdesian\, Advanced Nano Design Applications\, McGil
 l University\, Montréal\, QC\, Canada.There are several limitations to st
 udy the mammalian nervous system. Difficult access and very small dimensio
 ns are recurring problems in neuroscience. Neurons extend through differen
 t organs creating a very complex network\, where each connection has a spe
 cific role\, fundamental to the proper function of the whole system. Neuro
 nal connection and communication sites are called synapses\, which vary in
  size in the nanometer range. Therefore\, to investigate neuronal function
 \, degeneration and repair\, smaller and more precise tools are needed. We
  use microfluidics\, microfabrication and Atomic Force Microspcopy (AFM) t
 o grow and manipulate cellular development. We use microfluidics and micro
 fabrication to develop silicone microdevices to organize and align cells i
 n culture. Our microdevices enable the precise position of cells in rows m
 icrometers apart from each other\, promoting faster standardization of cul
 tures and results. AFM offers high resolution and versatility for imaging\
 , measuring\, and manipulating matter at the nanoscale. With these tools w
 e developed a new technique to create new\, functional neuronal connection
 s that can be used to directly (re)wire neuronal networks. Our findings ch
 allenge current understanding of the limits of neuronal growth and have di
 rect implications for the development of new therapies and surgical techni
 ques to achieve functional regeneration.Margaret Magdesian\, BSc Pharmacol
 ogy\, PhD Biochemistry (University of São Paulo)\, is the founder of ANA
 NDA and an associate researcher at the Montreal Neurological Institute (M
 NI) and the McGill Department of Physics.As an Associate Professor at t
 he Federal University of Rio de Janeiro (Brazil)\, her research focused on
  the identification of early diagnostic markers for neurodegenerative dise
 ases. Interested in the growing applications of nanotechnology in medicine
 \, in 2008 she joined the Neuroengineering group to work as a Visiting Sci
 entist with the director of the MNI\, Dr. David Colman. Since then she has
  been working in the development of new micro- and nanotools to study the 
 mechanism of neuronal degeneration and repair. Margaret has authored seve
 ral peer-reviewed papers and book chapters and she received an award from
  the International Brain Research Organization.Her work combines atomic fo
 rce microscopy\, microfabrication and microfluidic devices to culture diff
 erent cell types. These miniaturized versions of bioassays offer many adva
 ntages\, including: more physiological and biocompatible design\, low cost
 \, minimal reagent and sample requirements\, plus integration with other m
 icro- and nanoelectronic devices. She has also obtained 2 patents in the 
 area of microdevices.Seeing the opportunity to extend the use of the devel
 oped devices and techniques to other fields in medicine\, in 2013 Margaret
  launched ANANDA\, a joint venture between the MNI and the McGill Nanotoo
 ls Microfab to expand the use and development of new microdevices to impr
 ove biomedical research and diagnostics. In 2014 she was a winner in the 
 Innovation Driven Enterprise Track of the McGill Dobson Cup start-up compe
 tition.Voici le lien vers la page web du groupe de recherche du Dr. Magd
 esianCette conférence est présentée par le RQMP Versant Nord du Dépar
 tement de physique de l'Université de Montréal et le Département de g
 énie physique de Polytechnique Montréal.
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