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DTSTAMP:20260406T110729
DTSTART:20110318T113000
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URL:https://murmitoyen.com/events/vanille/udem/detail/35897
LOCATION:Université de Montréal - Pavillon Claire-McNicoll\, 2900\, chemi
 n de la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Molecular Dissection of Host /Pathogen interactions in EHEC\, EPEC 
 and C. rodentium infections
DESCRIPTION:Conférence du Dre Samantha Gruenheid\, professeure associée\,
  du Département de microbiologie et immunologie à l'Université McGill. 
 Cette conférence sera prononcée en anglais.Résumé Our lab is focused o
 n identifying and studying the molecules and pathways that play critical r
 oles during the interaction of bacterial pathogens with their hosts. We ex
 amine the host/pathogen interaction from both angles: the virulence mechan
 isms employed by bacteria to cause disease\, and the mechanisms employed b
 y the host to resist infection. The bacterial pathogens EHEC and EPEC atta
 ch to intestinal epithelial cells and use a 'molecular syringe\,' the type
  III secretion system to inject bacterial virulence proteins directly into
  host cells. NleA is a type III-translocated effector protein that is crit
 ical for virulence of EHEC\, EPEC and related pathogens. Current work in t
 he lab is focused on investigating the molecular and physiological basis f
 or nleA's striking effect on virulence\, in order to understand its role i
 n disease. Despite these and other sophisticated virulence mechanisms empl
 oyed by bacteria to cause disease within the host\, the outcome of infecti
 on can vary greatly between individuals. To further understand the varying
  host response to these infections\, we have also been applying a genetic 
 approach to the Citrobacter rodentium mouse infection model to identify ho
 st genes and proteins that play critical roles in susceptibility/resistanc
 e to infection with EHEC and related pathogens.Conférence présentée par
  le Département de microbiologie et immunologie de l'Université de Montr
 éal. Crédit photo : site Web du Département de microbiologie et immunol
 ogie 
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