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UID:69d3cc7ae2f06
DTSTAMP:20260406T110842
DTSTART:20110209T113000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20110209T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/34540
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Nucleophilic Organocatalytis
DESCRIPTION:Cette conférence sera prononcée par le professeur Hendrik Zi
 pse du Département de chimie la Ludwig-Maximilian-Universität à Munich
 \, Allemagne dans le cadre du programme d'échange international JCE MolCh
 em. Elle sera donnée en anglais. Résumé : Nucleophilic organocatalysi
 s is a rapidly developing area in contemporary catalysis research and invo
 lves the catalytic activity of Lewis bases such as aliphatic amines\, pyri
 dines\, or phosphanes. For the acylation of alcohols as a process of outst
 anding synthetic relevance we have developed new pyridine catalysts. These
  catalysts exceed the catalytic activity of the 'industry standard' DMAP b
 y a large margin. As a guideline for the development and optimization of 
 these catalysts we have used theoretically calculated data for the affinit
 y of potential catalysts towards model electrophiles such as the methyl ca
 tion and the acetyl cation. The calculated acetyl cation affinities are p
 articularly well suited for the development of acylation catalysts\, becau
 se they concern a central intermediate of the catalytic cycle. This has al
 so been shown in mechanistic studies\, in which the formal rate laws for t
 he acylation of structurally diverse alcohols have been determined. Buildi
 ng on these mechanistic insights the new catalysts have been employed to d
 evelop a simple direct esterification protocol using Boc2O as the activati
 ng agent. Information supplémentaire sur le conférencierInformation supp
 lémentaire sur JCE MolChem
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