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PRODID:https://murmitoyen.com/events/vanille/udem/
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BEGIN:VEVENT
UID:69e087305ad60
DTSTAMP:20260416T025232
DTSTART:20131113T113000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20131113T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/247959
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence du Professeur Floyd Romesberg (Scripps) à 11h30
DESCRIPTION:Titre :  Expansion of the Genetic Alphabet.La conférence sera
  prononcée par le professeur Floyd Romesberg du Département de chimie du
  Scripps Research Institute. Elle sera donnée en anglais. Attention\, ell
 e aura lieu exceptionnellement à 11h30.Résumé : Expansion of the geneti
 c alphabet to include a third base pair would be a fundamental accomplishm
 ent that would not only have immediate utility for a number of biotechnolo
 gy applications\, such as site-specific labeling of DNA and RNA\, but woul
 d also lay the foundation for a semi-synthetic organism with increased pot
 ential for information storage and retrieval.  We have developed a class 
 of unnatural base pairs\, exemplified by d5SICS-dNaM and dTPT3-dNaM\, that
  form based on packing and hydrophobic interactions rather than complement
 ary H-bonding\, but are nonetheless replicated and transcribed with effici
 encies and fidelities approaching those of a natural base pair.  Structur
 al studies\, as well as several practical applications of the unnatural ba
 se pairs will be discussed\, as will our recent progress towards replicati
 ng DNA containing an unnatural base pair within a living cell.Information 
 supplémentaire
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TZID:America/Montreal
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