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UID:69e0d3c74e3ba
DTSTAMP:20260416T081919
DTSTART:20130925T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20130925T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/247955
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence du Professeur Michael Organ (York)
DESCRIPTION:Titre :  Catalysts: Making Them Do What You Want Them To Do an
 d How You Do That.La conférence sera prononcée par le professeur Michae
 l Organ du Département de chimie de York University. Elle sera donnée en
  anglais. Résumé : The Pd N-Heterocyclic carbene (NHC)-based pre-cataly
 st based on bis N\,N-(2\,6-diisopropylphenyl) imidazolium (Pd PEPPSI-iPr) 
 has shown to be nicely reactive in a wide variety of cross-coupling proced
 ures. The catalyst has been examined in Suzuki-Miyaura\, Negishi\, and Kum
 ada-Tamao-Corriu couplings where it has shown very good reactivity. Within
  all of these families of reactions\, couplings involving sp\, sp2 and sp3
 centers have been examined and all possible combinations yield good to exc
 ellent conversions. In an attempt to gain understanding on the reactivity 
 of NHC-based catalysts\, an aggressive mechanistic study has been undertak
 en comprised of NMR spectroscopy\, computational methods\, and rate studie
 s. Clearly the size of the groups on the flanking N-phenyl substituents pl
 ays a key role in the reactivity of the Pd-NHC complex. Attempts have been
  made to construct a catalytic cycle for Pd-NHC complexes and to subsequen
 tly dissect it to see where sterics and/or electronics exert their greates
 t effects. This physical and structural analysis has led to the rational c
 reation of the second generation NHC catalyst based on bis N\,N-(2\,6-di(3
 -pentyl)phenyl) imidazolium\, i.e.\, Pd PEPPSI-iPent. This catalyst has be
 en further examined in catalyzed amination and sulfination\, in addition t
 o the carbon-carbon cross-coupling of intensively hindered and electronica
 lly-deactivated substrates\, where it has demonstrated the highest levels 
 of performance under the mildest conditions reported in these fields.Infor
 mation supplémentaire
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