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UID:69e18ef36bb17
DTSTAMP:20260416T213755
DTSTART:20130125T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20130125T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/175511
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence du Dr. Jean Duhamel (Waterloo)
DESCRIPTION:Titre : Probing the Internal Dynamics of Macromolecules in Solu
 tion Quantitatively by Using Time-Resolved Fluorescence.Cette conférence 
 sera prononcée (en anglais) par le Dr. Jean Duhamel du Waterloo Institute
  of Nanotechnology affilié à l'University of Waterloo. Ce dernier sera 
 à Montréal à titre d'examinateur externe d'une soutenance de thèse en 
 chimie. Résumé : The internal dynamics of macromolecules are involved i
 n a wide array of physical phenomena that include the folding of a randoml
 y coiled polypeptide in a 3-dimensional structured active enzyme\, the def
 ormation of an associative thickener under shear resulting in a massive dr
 op in the viscosity of the polymer solution\, or the shuttling of the chai
 n ends of a dendrimer decorated with a valuable cargo from the congested i
 nterior of the dendrimer to its interface with the solvent. We have introd
 uced the Fluorescence Blob Model (FBM) and Model Free Analysis (MFA) which
  together enable the quantitative analysis of the internal dynamics of an 
 incredibly wide variety of fluorescently labelled macromolecules. This tal
 k will illustrate this point with examples where the FBM was applied to de
 scribe the internal dynamics of pyrene-labelled polymers and the distribut
 ion of metal cations along DNA\, and where the MFA was employed to describ
 e the internal dynamics of pyrene-labelled dendrimers and the kinetics of 
 Fluorescence Resonance Energy Transfer (FRET) from the dendrimer ends to i
 ts core. Information supplémentaire
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