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DTSTAMP:20260417T083304
DTSTART:20120613T100000
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URL:https://murmitoyen.com/events/vanille/udem/detail/129198
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence CRMAA avec Antonella Bandiera
DESCRIPTION:Titre : Thermosensitive Self-Assembly: With a Little HELP from
  from Nature.Cette conférence sera prononcée par la professeure Antonel
 la Bandiera du département des sciences de la vie de l'Università degli 
 Studi di Trieste en Italie. Elle est commanditée par le Centre de recherc
 he sur les materiaux auto-assemblés (CRMAA) et sera donnée en anglais.R
 ésumé : Several elastin-based macromolecules have been developed exhibi
 ting peculiar biomechanical\, biochemical\, biological and biophysical pr
 operties that resemble those of the native protein. The most prominent is
  the propensity to self-aggregate in a solid phase from a solution under 
 appropriate conditions of concentration\, ionic strength and temperature. 
 It has been demonstrated that this behavior is due to the presence of the
  hydrophobic domains based on (VPGXG) repeated motifs\, characterizing th
 e bovine homolog. In our lab\, the regularly repeated domain from human t
 ropoelastin was chosen as a basic modulus to obtain repetitive recombinan
 t macromolecules that were named Human Elastin-Like Polypeptides (HELPs)\
 , in an effort toward the realization of a family of biomimetic biopolymer
 s with smart and tunable properties. The functionality of these products 
 can be further expanded by simply fusing bioactive domains to the C-termi
 nal region. Their thermoresponsive self-assembly is triggered by external
  stimuli\, mainly temperature and ionic strength. Thus they represent exc
 ellent candidates for temperature switch in many biomedical and biotechno
 logical applications. Significant interest is also focused on the success
 ful development of tailored\, bioactive materials that are compatible with
  cell viability and that could even control cell growth. Information sup
 plémentaire 
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