BEGIN:VCALENDAR
VERSION:2.0
PRODID:https://murmitoyen.com/events/vanille/udem/
X-WR-TIMEZONE:America/Montreal
BEGIN:VEVENT
UID:69d95394e1a65
DTSTAMP:20260410T154628
DTSTART:20190607T120000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20190607T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/876041-localizing-pep
 tidoglycan-synthesis-for-bacterial-growth-and-morphogenesis
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Localizing peptidoglycan synthesis for bacterial growth and morphog
 enesis
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nConférencier:
\nYves Brun\, PhD\,  titulaire de la Chaire de rec
 herche du Canada 150 sur la biologie cellulaire bactérienne\, professeur 
 titulaire\, Département de microbiologie\, infectiologie et immunologie\,
  Université de Montréal
\nRésumé:According to the World Health Organiz
 ation\, the recent dramatic increase in bacterial resistance to antibiotic
 s is one of our most urgent health challenges. By 2050\, antimicrobial res
 istence could be the cause of 10 million deaths per year globally. The bes
 t target for antibiotic development has been and continues to be the synth
 esis of the peptidoglycan cell wall\, which is required for bacterial grow
 th and morphogenesis. I will describe new methods of peptidoglycan labelin
 g that allow the detection of sites of peptidoglycan synthesis in live cel
 ls and in real time\, and their use to study the mechanisms of peptidoglyc
 an synthesis in cell growth and morphogenesis. For example\, these methods
  were used to show that pathogenic Chlamydia have peptidoglycan\, ending 5
 0 years of speculation and debate concerning the chlamydial anomaly\, and 
 to study the spatio-temporal dynamics of peptidoglycan synthesis at the si
 te of cell division in Bacillus subtilis.
\nI will describe the mechanisms
  that control morphological diversity in species related to Caulobacter cr
 escentus that synthesize appendage-like extensions of the cell envelope at
  distinct sub-cellular positions. I will show that stepwise evolution of a
  specific domain of a developmental regulator led to the gain of a new fun
 ction and localization of this protein\, which drove the sequential transi
 tion in morphology. Our results indicate that evolution of protein functio
 n\, co-option\, and modularity are key elements in the evolution of bacter
 ial morphology. In addition\, I will show how evolutionary consideration o
 f the mechanism of growth in the alphaproteobacteria led to the surprising
  discovery that polar growth\, rather than the previously assumed binary f
 ission\, is the predominant mode of growth in a large group of the alphapr
 oteobacteria that includes the plant pathogen Agrobacterium tumefaciens an
 d the human pathogen Brucella abortus.
END:VEVENT
BEGIN:VTIMEZONE
TZID:America/Montreal
X-LIC-LOCATION:America/Montreal
END:VTIMEZONE
END:VCALENDAR