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PRODID:https://murmitoyen.com/events/vanille/udem/
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UID:69d973b160601
DTSTAMP:20260410T180329
DTSTART:20190510T120000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20190510T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/871190-rational-diagn
 ostics-treatment-and-therapy-personalization
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Rational diagnostics\, treatment\, and therapy personalization
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nTitre complet
\nRational diagnostics\, treatment\, and therapy per
 sonalization of hemato-immune disorders through translational quantitative
  medicine  Conférencière:  Morgan Craig\, PhD\, professeure adjointe\, D
 épartement de mathématiques et de statistique\, Université de Montréal
 .
\nRésumé:The human hematopoietic system is responsible for producing s
 ome 500 billion blood cells per day. This stem cell system is particularly
  important as terminally differentiated blood cells are tasked with perfor
 ming a dizzying array of functions. Cytokines are small proteins expressed
  by blood cells and other key organs that act as long-distance signals to 
 up- or down-regulate key processes within the hematopoietic and immune (he
 mato-immune) systems. The sheer number of cell/cytokine interactions compl
 icates our ability to understand\, at a broad scale\, the totality of  re
 lationships within the hemato-immune systems\, and the pathophysiology of 
 blood and immune disorders.
\nTo better design\, develop\, and administer 
 therapies\, we must discern the physiological mechanisms (pathological or 
 not) regulating drug effects. Quantitative medicine\, an emerging field in
 tegrating (patho)physiology\, pharmacometrics\, mathematics/statistics\, a
 nd computational biology/machine learning\, allows us to translate from me
 chanism to disease to therapy to answer foundational questions about how d
 iseases develop\, how to address disorders as they progress\, and how best
  to stay healthy.
\nThis talk will highlight three principal axes of my re
 search dealing with how we understand and treat hemato-immune disorders\, 
 and leverage immune mechanisms as therapies. I will discuss how I use comp
 utational biology in complement with experimental and clinical data to 1) 
 understand healthy hemato-immune regulation to identify pathophysiological
  mechanisms of rare blood disorders\, 2) rationalize the treatment of HIV 
 with long-acting agents\, and 3) translate from mechanism to therapy to pe
 rsonalize cancer immunotherapy.
\n               
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TZID:America/Montreal
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