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URL:https://murmitoyen.com/events/vanille/udem/detail/866881-an-engineered-
 multicellular-stem-cell-niche-for-the-3d-derivation-of-human-myogenic-prog
 enitors-from-ipscs
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:An Engineered Multicellular Stem Cell Niche for the 3D Derivation o
 f Human Myogenic Progenitors from iPSCs
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nTitre complet:
\nAn Engineered Multicellular Stem Cell Niche for t
 he 3D Derivation of Human Myogenic Progenitors from iPSCs   Conférencier:
  C. Florian Bentzinger\, PhD\, professeur adjoint\, Université de Sherbr
 ooke\, Département de pharmacologie-physiologie\, Faculté de médecine 
 et des sciences de la santé
\nRésumé:One of the most fundamental proble
 ms associated with stem cell therapy of skeletal muscle is the limited ava
 ilably of cells that can robustly engraft into the stem cell compartment. 
 For decades\, it has been attempted to isolate muscle progenitors from adu
 lt skeletal muscle and expand them in culture to obtain sufficient cells f
 or such treatments. However\, over the years it became clear that once iso
 lated from their niche and maintained in culture\, adult muscle progenitor
 s become terminally committed to differentiation and display a dramaticall
 y reduced engraftment potential. The discovery of induced pluripotent stem
  cells (iPSCs) has opened new avenues for the in-vitro generation of large
  quantities of myogenic cell types with embryonic characteristics and a su
 perior capacity for engraftment. Our recent work has uncovered a scalable 
 and highly efficient protocol for the derivation of uncommitted muscle pro
 genitors from human iPSCs in suspension embryoids. Compared to myogenic ce
 lls isolated from adult human skeletal muscle\, embryoid derived progenito
 rs display markedly enhanced migration\, engraftment into the satellite ce
 ll position\, and restoration of dystrophin expression when transplanted i
 nto muscles of a mouse model of Duchenne muscular dystrophy. Altogether\, 
 by combining niche-engineering and biochemical pathway targeting\, we esta
 blished a powerful method for 3D myogenic hiPSC differentiation with uniqu
 e disease modeling and cell therapy applications. 
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