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DTSTAMP:20260410T215049
DTSTART:20190315T110000
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URL:https://murmitoyen.com/events/vanille/udem/detail/862381-conference-de-
 chimie-avec-le-professeur-xiaoguang-lei
LOCATION:Université de Montréal - Pavillon Claire-McNicoll\, 2900\, chemi
 n de la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence de chimie avec le Professeur  Xiaoguang LEI
DESCRIPTION:
Titre : Efficient Total Synthesis of Complex Natural Products
  via Sequential C-H Functionalizations



Endroit : Pavillon Claire-McNico
 ll\, Salle Z-317

Hôte : Shawn Collins

résumé : Structurally complex
  and bioactive natural products provide tremendous opportunities to shape 
 the landscape of organic synthesis\, as well as to impact the biomedical r
 esearch and drug discovery. My laboratory conducts research at the interfa
 ce between chemistry and biology. We systematically use bioactive small mo
 lecules\, particularly natural products\, to study their biological functi
 ons\, elucidate molecular mechanisms of the important biological pathways\
 , and develop novel therapeutic agents for currently intractable diseases.
  However\, traditionally total synthesis of complex natural product could 
 only provide small quantity of material\, which significantly hinders the 
 subsequent application. Therefore\, the ability to procure useful quantiti
 es of complex molecules by simple\, scalable routes is emerging as an impo
 rtant goal in natural product synthesis. Selective C-H functionalization h
 as emerged as an ideal tool for organic synthesis for the past decade\, ye
 t chemists still struggle to apply the newly developed synthetic methodolo
 gy to construct complex and highly functionalized molecules through a prac
 tical process. Therefore\, the development of conceptually new approach us
 ing selective C-H functionalization catalysis is of particular interest an
 d will ultimately enable synthetic chemist to obtain sufficient quantities
  of complex molecules for further biological studies. Herein\, I would lik
 e to disclose our recent endeavors towards the practical and scalable tota
 l syntheses of a number of interesting natural products through selective 
 and sequential C-H functionalization catalysis.


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