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UID:69da9529e486c
DTSTAMP:20260411T143833
DTSTART:20180523T110000
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TRANSP:OPAQUE
DTEND:20180523T110000
URL:https://murmitoyen.com/events/vanille/udem/detail/819092-remote-functio
 nalization-par-le-professeur-ilan-marek-israel
LOCATION:Pavillon Roger-Gaudry \, 2900\, boul. Édouard-Montpetit\, Local M
 -415\, Montréal\, QC\, Canada
SUMMARY:Remote functionalization par le professeur Ilan Marek (Israel)
DESCRIPTION:Conférence présentée par le professeur Ilan Marek\, du Techn
 ion - Israel Institute of Technology
\nRésumé : Combining functionaliza
 tion at a distant position from a reactive site with the creation of sever
 al consecutive stereogenic centers\, including the formation of one or mor
 e quaternary carbon stereocenters\, in acyclic system represents a pinnacl
 e in organic synthesis. Here we report the regioselective transformation o
 f terminal olefins as a distant trigger for the ring-opening of cyclopropa
 nes. This metal-catalyzed unfolding of the strained cycle\, driving force 
 of the chain-walking process\, remarkably proved its efficiency and versat
 ility\, as the reaction proceeded regardless of the molecular distance bet
 ween the initiation (double bond) and termination sites. Moreover\, employ
 ing stereodefined polysubstituted cyclopropane vaults allowed to access so
 phisticated stereoenriched acyclic scaffolds in good yields.
\nInformation
 s supplémentaires
\nAnnonce PDF de la conférence
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