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UID:69dac27b87e0c
DTSTAMP:20260411T175155
DTSTART:20180413T133000
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URL:https://murmitoyen.com/events/vanille/udem/detail/813273-seminaire-etud
 iant-m-ethan-yang-groupe-chaurand
LOCATION:Pavillon Roger-Gaudry \, 2900\, boul. Édouard-Montpetit\, Local M
 -415\, Montréal\, QC\, Canada
SUMMARY:Séminaire étudiant: M. Ethan Yang (Groupe Chaurand)
DESCRIPTION:Titre : ''Invertigating Ganglioside Distribution in Tissue Samp
 les with Imaging Mass Spectrometry ''
\nEndroit : Pavillon Roger-Gaudry\,
  salle G-415 à 13 h 30
\nCette conférence sera prononcée par Monsieur 
 Ethan Yang\, candidat au doctorat\, étudiant du Professeur Pierre Chauran
 d\, au département de chimie\, de l'Université de Montréal.
\nRÉSUMÉ:
  Gangliosides represent a family of surface-membrane glycosphingolipids mo
 st abundant in neuronal cells. Important in signalling and other biologica
 l functions\, its dysregulation and bioaccumulation have been implicated i
 n numerous neurological diseases (Alzheimer’s\, Parkinson’s\, Hunter
 ’s) as well as cancers (neuroblastoma\, breast cancer). Because of its a
 bility to simultaneously detect multiple gangliosides and distinguish betw
 een the same species of gangliosides with different fatty acid chain lengt
 hs\, imaging mass spectrometry (IMS) is an ideal technique for elucidating
  the role of gangliosides in these diseases and their potential as biomark
 ers. Unfortunately\, method development for ganglioside IMS detection and 
 imaging at cellular length scale are sparse. My project focuses on develop
 ing and validating an IMS protocol for the detection of these molecules us
 ing matrix assisted laser desorption/ionization time-of-flight mass spectr
 ometry (MALDI-TOF MS). As of now\, different sample preparation and matrix
  deposition parameters were optimized for a protocol that has demonstrated
  an improved sensitivity of over 10-fold\, and an increase in the number o
 f ganglioside species detected from 5 to 15. This methodology allows for d
 own to 20 μm spatial resolution imaging and has the potential for even hi
 gher resolution. The next step is to validate the protocol using disease m
 odels to shed light on the biological importance of gangliosides in diseas
 e onset and development.
\n 
\n        Informations supplémentair
 es 
\n        Annonce PDF du séminaire
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