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PRODID:https://murmitoyen.com/events/vanille/udem/
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UID:69dac27231ce8
DTSTAMP:20260411T175146
DTSTART:20180316T120000
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TRANSP:OPAQUE
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URL:https://murmitoyen.com/events/vanille/udem/detail/811688-in-vivo-metabo
 lic-rewiring-via-crispr-cas9-based-genome-editing
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:In vivo metabolic rewiring via CRISPR-Cas9-based genome editing
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nConférencier :Yannick Doyon\, PhD (invitée pour l'axe Santé m
 étabolique et cardiovasculaire)
\n
\nChercheur régulier\, Axe Reproducti
 on\, santé de la mère et de l’enfant\, Centre de recherche du CHU de Q
 uébec – Université Laval
\nProfesseur adjoint\, Département de médec
 ine moléculaire\, Université Laval
\n
\nBiographie :I established my lab
 oratory at the CHU de Québec–Université Laval research center in Septe
 mber 2013 after a seven-year postdoctoral stint in the biotechnology secto
 r (Sangamo Therapeutics\, California\, USA) devoted to the creation and im
 plementation of genome-editing tools. My team develops versatile methods f
 or increasing the efficacy of targeted genome editing to enable the creati
 on of bona fide cellular models for biological research. In addition\, we 
 explore the potential of in vivo genome editing as a novel class of human 
 therapeutics for pediatric metabolic disorders.
\nRésumé :In this semina
 r\, I will share our recent results demonstrating that CRISPR-Cas9 systems
  can be used to dissect metabolic pathways in vivo. Using a mouse model of
  hereditary tyrosinemia\, we uncovered intra-pathway enhancers and suppres
 sors that modulate the phenotype and the levels of key catabolites of the 
 pathway. I will also describe our approach to streamline the incorporation
  of marker-free genetic changes in human cells (Agudelo et al\, Nature met
 hods 2017).
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