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DTSTAMP:20260411T175101
DTSTART:20180302T120000
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URL:https://murmitoyen.com/events/vanille/udem/detail/810349-self-reactive-
 t-cells-many-shades-of-gray
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Self-reactive T cells: many shades of gray
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nConférencière :Heather Melichar\, PhD (invitée pour l'axe Mal
 adies immunitaires et cancers)\, professeure sous octroi adjointe\, Dépar
 tement de médecine\, Université de Montréal et chercheuse au Centre de
  recherche de l'Hôpital Maisonneuve-Rosemont. 
\nBiographie :Dr. Melichar
  pursued her doctoral studies in the lab of Dr. Joonsoo Kang at the Univer
 sity of Massachusetts Medical School focusing on the molecular mechanisms 
 influencing ab vs. gd T cell fate decisions. She then moved to the west co
 ast and began a postdoctoral fellowship at the University of California\, 
 Berkeley\, with Dr. Ellen Robey where she developed novel platforms to stu
 dy the development and behaviour of both murine and human T cells in situ.
  In 2014\, Dr. Melichar established her independent research group in Mont
 real. As an FRQS Junior 1 Scholar and CIHR New Investigator award recipien
 t\, Dr. Melichar is currently a researcher at the Maisonneuve-Rosemont Hos
 pital Research Center and Assistant Professor in the Department of Medicin
 e at the University of Montreal. Her laboratory is interested in the cellu
 lar and molecular mechanisms that regulate the development and function of
  T cells and uses insights from these studies to improve the efficacy of c
 ellular therapies.
\nRésumé :T cells function to eliminate abnormal or i
 nfected cells. They distinguish\, with incredible specificity\, self- from
  foreign-peptides\, and there are multiple regulatory layers in place to p
 revent the generation and activation of T cells that bind with high affini
 ty to self-antigens. However\, interactions between T cells and self-pepti
 de are required for the development of functional T cells in the thymus\, 
 their survival in the periphery\, and their expansion in lymphopenic envir
 onments. These low-affinity interactions do not cause overt T cell activat
 ion\, but are implicated in the establishment of functional heterogeneity 
 within the T cell compartment. The goal of our lab is to understand how su
 btle differences in self-reactivity influence T cell development and funct
 ion. We approach this problem from a cellular perspective\, studying how T
  cells communicate with support cells in the thymic microenvironment throu
 ghout their development and how these interactions influence their functio
 n in the peripheral lymphoid organs.
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