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PRODID:https://murmitoyen.com/events/vanille/udem/
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UID:69dad4da4a017
DTSTAMP:20260411T191018
DTSTART:20180202T120000
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DTEND:20180202T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/805770-lysosome-homeo
 stasis-remodeling-and-integrity-by-the-intralumenal-fragment-pathway
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Lysosome homeostasis\, remodeling and integrity by the IntraLumenal
  Fragment pathway
DESCRIPTION:Conférence scientifique | Centre de recherche du CHU Sainte-Ju
 stine
\nLysosome homeostasis\, remodeling and integrity by the IntraLumena
 l Fragment pathway
\nConférencier :
\nChristopher Brett\, Ph.D. (pour l'
 axe Maladies immunitaires et cancers)Professeur agrégé de biologieUniver
 sité Concordia\, Montréal\, Canada
\nBiographieDr. Christopher Brett is 
 a cell biologist and Associate Professor of Biology at Concordia Universit
 y in Montreal. His research group studies lysosome physiology primarily us
 ing baker’s yeast (Saccharomyces cerevisiae) and its vacuolar lysosome a
 s models. Found within all eukaryotic cells\, lysosomes are miniature biom
 aterial recycling centers important for clearing toxins\, coordinating sig
 nals and supplying nutrients. These functions are critical for survival an
 d underlie diverse physiology. As such\, lysosomal dysfunction contributes
  to many human diseases\, e.g. cancers and Alzheimer’s disease. Three fu
 ndamental processes are required for lysosome function: membrane fusion to
  receive biomaterials\, breakdown of biomaterials into their constituents 
 by lumenal acid hydrolases\, and translocation of products (amino acids\, 
 nucleotides\, lipids) across the lysosome membrane by nutrient transporter
  proteins so that they may be reused by the cell. Despite their importance
  to physiology\, relatively little is known about lysosomal nutrient trans
 porter proteins\, including how their activities or lifetimes are controll
 ed. However\, Dr. Brett’s group recently discovered a new cellular pathw
 ay responsible for regulating their lifetimes that relies on generation of
  IntraLumenal membrane Fragments (ILFs) during lysosome membrane fusion. T
 ermed the ILF pathway\, this mechanism selectively clears transporter prot
 eins from lysosome membranes and degrades them in response to substrates\,
  misfolding or cell signaling. Together with a second\, similar mechanism\
 , termed the vReD pathway\, his group found that the ILF pathway is critic
 al for lysosome homeostasis\, remodeling and integrity necessary for cell 
 metabolism\, proteostasis and protection against cell death. Distinct unde
 rlying mechanisms and contributions of each pathway to physiology and dise
 ase will be discussed.
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TZID:America/Montreal
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