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UID:69dae83b1cd58
DTSTAMP:20260411T203259
DTSTART:20180124T110000
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TRANSP:OPAQUE
DTEND:20180124T110000
URL:https://murmitoyen.com/events/vanille/udem/detail/798647-from-fuzzy-to-
 function-in-gene-activation
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:From Fuzzy to Function in Gene Activation
DESCRIPTION:Conférence prononcée par  Anna Mapp\, professeure au départ
 ement de chimie de l'Université du Michigan.
\nRésumé : Within the chem
 ical space of protein-protein interactions (PPIs)\, transient\, modest aff
 inity PPIs play a central role in a variety of cellular functions\, includ
 ing protein folding and transcription. Dysregulation of this class of PPIs
  is at the heart of diseases ranging from cancer to neurodegenerative diso
 rders. For example\, in several types of AML\, leukemogenesis is dependent
  upon the loss of one transcriptional activator-coactivator interaction (M
 LL-p300) and the maintenance or amplification of a second (cMyb-p300). Des
 pite their importance and their prevalence\, such transient and modest aff
 inity PPIs are often classified as ‘undruggable’\, with few successful
  strategies for small molecule modulator discovery. A significant challeng
 e has been that the binding partners often have significant disorder and a
 re thus difficult to characterize structurally alone or in complex. A stra
 tegy for the identification of chemical co-chaperones that capture particu
 lar conformations of transcriptional coactivators and in doing so selectiv
 ely modulate the assembly of transcriptional activator-coactivator complex
 es in vitro and in cells will be described.
\nHôte : André Charette\, pr
 ofesseur à l'Université de Montréal.
\n
\nInformation supplémentaire
\
 nAnnonce PDF de la conférence
\n
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