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UID:69dbc3b706162
DTSTAMP:20260412T120927
DTSTART:20170321T150000
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URL:https://murmitoyen.com/events/vanille/udem/detail/758480-an-epigenetic-
 signaling-axis-in-stem-cells-mouse-development-and-human-disease
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:An epigenetic signaling axis in stem cells\, mouse development and 
 human disease
DESCRIPTION:CONFÉRENCE SCIENTIFIQUE de l'Unité collaborative en épigén
 étique moléculaire (UCEM) 
\n 
\nInvitation des Drs Noël Raynal et Ser
 ge McGraw 
\n 
\nXiang-Jiao Yang\, PhD Professeur\, Goodman Cancer Center
  & Department of Medecine\, McGill University
\n 
\nAn epigenetic signali
 ng axis in stem cells\, mouse development and human disease 
\n 
\nIn the
  past two decades\, it has become clear that epigenetic regulation provide
 s the plasticity for cell- and tissue-specific expression of genetic infor
 mation. For epigenetic regulation\, both DNA and associated proteins such 
 as histones are subject to multiple covalent modifications. There are enzy
 mes executing such modifications\, as well as protein domains recognizing 
 these modifications to transmit epigenetic information. In this talk\, I w
 ill first outline a conceptual path from molecular identification of two p
 aralogous histone-modifying enzymes and their multisubunit complexes to el
 ucidating their functions in modifying histone H3 at a specific lysine res
 idue. Using results from mouse and human genetic approaches\, I will then 
 show that the enzymatic complexes are important for regulating neural and 
 hematopoietic stem cells during mouse development. I will also show that d
 ysreguation of these complexes in human patients causes cancer and develop
 mental disorders. At the end\, I will discuss some treatment options for r
 elated diseases.
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