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DTSTAMP:20260412T104039
DTSTART:20170419T110000
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URL:https://murmitoyen.com/events/vanille/udem/detail/740370-innovative-mas
 s-spectrometry-chemistries-and-technologies
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Innovative Mass Spectrometry Chemistries and Technologies
DESCRIPTION:Conférence Thermo Fisher
\nTitre complet :Innovative Mass Spec
 trometry Chemistries and Technologies to reed the Complex Language of Biol
 ogy
\nCette conférence sera prononcée (en anglais) par le professeur 
 David Muddiman du département de chimie de l'Université NC State.
\nRé
 sumé : Mass spectrometry offers the most robust platform to discover and 
 characterize new diagnostic\, prognostic\, and therapeutic biomarkers for 
 ovarian cancer across all molecular classes. Moreover\, a systems biology 
 approach will allow the underlying biology of ovarian cancer to be underst
 ood. This presentation will discuss the challenges specific to the study o
 f epithelial ovarian cancer (EOC) in humans and how these challenges have 
 directed our thinking\, in terms of the development of model organisms and
  mass spectrometry-based bioanalytical strategies. First\, to augment the 
 human model\, we developed the domestic hen model of spontaneous EOC\, whi
 ch allowed us to longitudinally sample the rapid onset and progression of 
 the disease in a controlled environment. Second\, we developed bioanalytic
 al tools to characterize structurally challenging analytes that are critic
 al to a systems-level analysis. To increase the electrospray response of N
 -linked glycans\, perform stable-isotope relative quantification\, and sem
 i-automated data analysis\, we synthesized novel hydrophobic tagging reage
 nts (INLIGHTTM). Furthermore\, we developed a novel ionization technique f
 or tissue imaging of lipids and metabolites. This unique model organism ha
 s and continues to provide new insights into the biology of ovarian cancer
 \; combined with other –OMICS data obtained through these novel bioanaly
 tical approaches\, we will understand the origin of ovarian cancer and ult
 imately translate that knowledge to humans.
\nHôte : Professeur Pierre T
 hibault
\nInformation supplémentaireBrochure de la conférence
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