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URL:https://murmitoyen.com/events/vanille/udem/detail/737879-bringing-new-c
 hemistry-to-life
LOCATION:Pavillon Roger-Gaudry \, 2900\, boul. Édouard-Montpetit\, Local M
 -415\, Montréal\, QC\, Canada
SUMMARY:Bringing new chemistry to life
DESCRIPTION:Titre 1 : ''Innovation by evolution: expanding the enzyme unive
 rse'' (30 mars 2017)
\nTitre 2: “Bringing new chemistry to life” (31 m
 ars 2017)
\nHôte : Professeur Shawn Collins
\nCette conférence sera pr
 ononcée (en anglais) par la professeure Frances Arnold de la California 
 Institute of Technology (Caltech).
\nRésumé :Not satisfied with nature
 ’s vast catalytic repertoire\, we want to create new enzymes and expand 
 the space of genetically encoded chemical reactions. I will describe how w
 e can use the most powerful biological design process\, evolution\, to opt
 imize existing enzymes and invent new ones. Mimicking nature’s evolution
 ary tricks and using a little chemical intuition\, we can generate whole n
 ew enzyme families that catalyze important reactions not (yet) known in na
 ture\, thereby adding new capabilities to the chemistry of the biological 
 world and increasing the scope of molecules and materials we can build. I 
 will show that heme proteins can catalyze an array of increasingly challen
 ging carbene- and nitrene-transfer reactions and that these new activities
  can be enhanced by directed evolution. Unlike small-molecule catalysts de
 scribed for some of these reactions\, the new heme enzymes are made microb
 ially from renewable resources\, use earth-abundant iron\, function in aqu
 eous media under ambient conditions\, and are highly selective.
\nBiograph
 ie : As Dickinson Professor at the California Institute of Technology\, Fr
 ances Arnold’s research focuses on protein engineering by directed evolu
 tion\, with applications in alternative energy\, chemicals\, and medicine.
  She has a BS in Mechanical and Aerospace Engineering from Princeton Unive
 rsity and a PhD in chemical engineering from UC Berkeley. Dr. Arnold’s h
 onors include the Millennium Technology Prize (2016)\, the Eni Prize in Re
 newable and Nonconventional Energy (2013)\, the US National Medal of Techn
 ology and Innovation (2011)\, and the Charles Stark Draper Prize of the US
  National Academy of Engineering (2011). She was inducted into the US Nati
 onal Inventors Hall of Fame in 2014 and has been elected to membership in 
 all three US National Academies\, of Science\, Medicine\, and Engineering.
  She was elected to the American Academy of Arts and Sciences in 2011 and 
 has honorary doctorates from Stockholm University\, the ETH Zurich\, and t
 he University of Chicago. Arnold chairs the Advisory Panel of the David an
 d Lucile Packard Foundation Fellowships in Science and Engineering program
  and serves as a judge for the Queen Elizabeth Prize in Engineering.
\nArn
 old holds more than 50 US patents and is active in technology transfer. Sh
 e is a Director of Illumina and Provivi and has served on numerous science
  advisory boards. She co-founded Gevo\, Inc. in 2005 to make fuels and che
 micals from renewable resources and Provivi\, Inc. in 2013 to develop non-
 toxic modes of agricultural pest control.
\nInformation supplémentaireBro
 chure de la conférence
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