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PRODID:https://murmitoyen.com/events/vanille/udem/
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BEGIN:VEVENT
UID:69dc1b71039e5
DTSTAMP:20260412T182345
DTSTART:20161202T120000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20161202T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/734247-cellular-senes
 cence-drives-pathological-retinal-angiogenesis
LOCATION:CHU Sainte-Justine\, 3175\, Chemin de la Côte-Sainte-Catherine\, 
 Montréal\, QC\, Canada\, H3T 1C5
SUMMARY:Cellular senescence drives pathological retinal angiogenesis
DESCRIPTION:Conférence de Mike Sapieha\, PhD\, chercheur au Centre de rech
 erche de l’Hôpital Maisonneuve-Rosemont et professeur agrégé au Dépa
 rtement d’ophtalmologie de l’Université de Montréal.
\nRésuméPatho
 logical retinal neovascularization is the hallmark of primary blinding dis
 eases such as diabetic retinopathy\, age related macular degeneration and 
 retinopathy of prematurity\, yet surprisingly little is known about the ca
 usative factors. These diseases are characterized by an initial breakdown 
 of vascular beds that yield hypoxic/ischemic central nervous tissue subjec
 ted to a constellation of biochemical and inflammatory stressors that comp
 romise cellular function. While much effort has been invested in understan
 ding the ensuing wave of pathological pre-retinal angiogenesis\, relativel
 y little is known of the cellular processes at play during the precursory 
 state of neural tissue hypoxia. We will discuss novel paradigms in CNS isc
 hemia and elaborate on the role of mechanisms that help weather neural hyp
 oxia such as ER-stress and cellular senescence and how they paradoxically 
 become drivers of destructive angiogenesis.
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