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UID:69dc62e798d6b
DTSTAMP:20260412T232839
DTSTART:20161028T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20161028T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/716442-seminaire-de-l
 etudiant-nagavenkata-durga-prasad-atmuri-groupe-lubell
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Séminaire de l'étudiant Nagavenkata Durga Prasad Atmuri (Groupe L
 ubell)
DESCRIPTION:Titre : Design\, Synthesis and Biomedical Applications of Azabi
 cyclo[X.Y.0]alkanone Amino Acids
\nEndroit : Pavillon J.-Armand Bombardier
 \, salle 1035 à 11 h 00.
\nCette conférence sera prononcée par Monsie
 ur Nagavenkata Durga Prasad Atmuri\, étudiant au doctorat\, du laboratoi
 re de William Lubell\, professeur au Département de chimie de l'Universit
 é de Montréal.
\nRésumé: Electrophilic transannular cyclization of 8-\
 , 9-\, and 10-membered macrocyclic dipeptide lactams has been shown to giv
 e effective entry to azabicyclo[X.Y.0]alkanone amino acid derivatives poss
 essing 5\,5-\, 5\,6-\, 6\,5-\, 6\,4-\, 6\,6-\, and 7\,5-fused ring systems
 . Our presentation describes this synthetic strategy starting from the pre
 paration and coupling of vinyl-\, allyl-\, homoallyl- and homohomoallylgly
 cine building blocks to prepare dipeptides that undergo ring-closing metat
 hesis furnishing the macrocyclic lactams.  Transannular iodolactamization
  gave typically azabicyclo[X.Y.0]alkanone possessing iodine on the lactam 
 ring.  X-ray crystallographic and spectroscopic analyses of the 8-\, 9- \
 , and 10-member macrocycles\, as well as certain bicycle analogs demonstra
 te their potential to serve as constrained dipeptides that mimic the centr
 al residues of ideal β-turn geometry. Moreover\, palladium catalyzed aryl
 ation of dehydro-indolizidin-2-one analogs has been developed and employed
  to prepare analogues of prostaglandin F2alpha receptor modulators for exa
 mination in myometrial contraction assays as potential agents for delaying
  preterm birth.
\nInformation supplémentaireAnnonce PDF du séminaire
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