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DTSTART:20160519T103000
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URL:https://murmitoyen.com/events/vanille/udem/detail/682427-pushing-the-fr
 ontiers-of-live-cell-monitoring-using-organic-electronics-n-rm-owens-ecole
 -des-mines-de-st-etienne-france
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Pushing the frontiers of live-cell monitoring using organic electro
 nics – R.M Owens\, Ecole des Mines de St. Etienne\, France
DESCRIPTION:Róisín Owens\, Maître Assistante (Associate Professor)\, D
 epartment of Bioelectronics\, Ecole Nationale Supérieure des Mines\, CMP
 -EMS\, Centre Microélectronique de Provence\, 880\, route de Mimet\, 1
 3541 Gardanne\, FRANCE.
\n Organic bioelectronics refers in part to the 
 coupling of conducting polymer based devices with biological systems\, pro
 ven repeatedly in the last decade to provide numerous advantages to a wide
  variety of biomedical applications in terms of sensitivity\, specificity 
 and most importantly\, bridging of the biotic/abiotic interface. We focus 
 on the unique properties of organic electronic materials that allow easy p
 rocessing\, and flexibility in design as well as chemical tunability\, to 
 develop state-of-the-art tools to (1) develop relevant in vitro models by 
 creating more ‘in vivo’ like environments and (2) monitor cells i.e. f
 or diagnostic purposes following exposure to toxins or pathogens. We have 
 successfully demonstrated the use of the organic electrochemical transisto
 r (OECT) for monitoring in vitro models of the gastrointestinal tract\, th
 e kidney and the blood brain barrier. For each application\, we attempt to
  recreate the in vivo conditions through the use of microfluidics\, biofun
 ctionalised materials\, and combinations of different cell types\, while s
 imultaneously designing the materials/devices in the most appropriate form
  factor to suit the model at hand. Our goal is to develop physiologically 
 relevant in vitro models with integrated monitoring systems that obviate t
 he need for animal experimentation in diagnostics\, toxicology or drug dev
 elopment. In this presentation\, I will focus on new work that we have car
 ried out to increase the sensitivity of our devices for monitoring a broad
 er selection of tissues in vitro\, integration of our devices with cells i
 n 3D formats\, and finally\, inclusion of multi-parameter monitoring by ad
 ditional functionalities such as metabolite sensing and high resolution op
 tical imaging.
\n Site web du groupe de la Pre Owens
\nCette conférence
  est présentée par le RQMP Versant Nord du Département de physique de
  l'Université de Montréal et le Département de génie physique de Pol
 ytechnique Montréal.
\nBiographie:
\nRóisín Owens is an Associate Profe
 ssor in the Department of Bioelectronics at the Centre Microélectronique 
 de Provence. She received her BA in Biochemistry at Trinity College Dublin
 \, and her PhD in Biochemistry and Molecular Biology at Southampton Univer
 sity. In her early postdoc work she specialized on biochemical aspects of 
 infectious diseases\, including enteric pathogens and tuberculosis\, but t
 hen moved into novel therapeutics (for rhinovirus) using protein engineeri
 ng and development of new technologies for pathogen detection. A continued
  interest in novel engineering technologies for biological applications le
 d her to the field of organic bioelectronics. Her current research centers
  on application of organic electronic materials for in vitro toxicology\, 
 with a specific interest in understanding the biotic/abiotic interface. Sh
 e has received several awards including the European Research Council star
 ting and proof of concept grants\, a Marie Curie fellowship\, and an EMBO 
 fellowship. In 2014\, she became principle editor for biomaterials for MRS
  communications (Cambridge University Press)\, and she serves on the advis
 ory board of Materials research express (IOP publishing) and Journal of Ap
 plied Polymer Science (Wiley)
\n 
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