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DTSTAMP:20260413T101603
DTSTART:20160224T110000
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URL:https://murmitoyen.com/events/vanille/udem/detail/681031
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence de Delphine Bouilly\, Ph.D. (Columbia)
DESCRIPTION:Titre : Single-Molecule Biosensors Using Nanoscale Electronic D
 evices.Endroit : Pavillon Roger-Gaudry\, salle G-615 à 11 h.Hôte : Profe
 sseur André Charette.
\nCette conférence sera prononcée (en français)
  par Delphine Bouilly\, Ph.D.\, actuellement chercheuse postdoctorale dans
  le groupe du Prof. Colin Nuckolls au sein du Département de chimie de la
  Columbia University.
\nRésumé :Organic macromolecules like proteins and
  nucleic acids regulate a wide variety of fundamental physiological proces
 ses\, yet they are difficult to observe individually due to their small si
 ze\, rapid fluctuations and complex environment. My research focuses on th
 e design and application of single-molecule electronic biosensors\, which 
 are miniature electrical circuits capable to capture and probe individual 
 biomolecules\, in real time and over a uniquely-wide range of timescales. 
 In this presentation\, I will describe my results in developing original a
 nd robust single-molecule device architectures that are able to detect\, t
 hrough quantized fluctuations in electrical conductance\, successive chemi
 cal reactions and conformational changes occurring on the same individual 
 molecule. In particular\, I will present recent experiments investigating 
 the conformational dynamics of human telomeric DNA\, by isolating an indiv
 idual single-stranded DNA sequence and observing its repeated\, reversible
  folding into a G‑quadruplex structure. Finally\, I will discuss my plan
 s to expand this emerging technique to explore other biomolecular mechanis
 ms\, for instance DNA hybridization\, enzyme catalysis or protein folding\
 , and to develop lab‑on‑chip technology for biomarker-based diagnosis 
 and monitoring.
\nInformation supplémentaire sur le groupe NuckollsAnnonc
 e PDF de la conférence
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