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DTSTAMP:20260413T073235
DTSTART:20160420T110000
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DTEND:20160420T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/671474
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence du Professeur Philip Britz-McKibbin (McMaster)
DESCRIPTION:Titre : Chemical Separations for Metabolomics: New Advances in 
 Biomarker Discovery for Population Health.Endroit : Pavillon J-A.-Bombardi
 er\, salle 1035 à 11 h.Hôte : Professeur Karen Waldron.
\nCette confére
 nce sera prononcée (en anglais) par le professeur Philip Britz-McKibbin 
 du Département de chimie et de biologie chimique au sein de de la McMaste
 r University.
\nRésumé : The future of medicine requires innovations in 
 evidence-based interventions that promote disease prevention and healthy l
 iving on a population level. Comprehensive metabolite profiling (i.e.\, me
 tabolomics) offers a holistic approach for understanding the phenotype of 
 an organism at a molecular level that is closely associated with clinical 
 outcomes. However\, the metabolome remains largely uncharacterized in comp
 lex biological samples notably when considering thousands of bioactive sma
 ll molecules derived from the diet and lifelong environmental exposures. A
 n introduction to capillary electrophoresis (CE) and CE-mass spectrometry 
 (MS) technology will first be presented in the context of public health in
 itiatives for human disease prevention. Recent strategies for enhancing sa
 mple throughput\, data fidelity and unknown identification in metabolomics
  will also be discussed for biomarker discovery when using multiplexed sep
 arations in conjunction with signal pattern recognition and high accuracy 
 tandem MS. Pre-analytical and post-analytical variables that contribute to
  false discoveries will be outlined when evaluating the metabolic phenotyp
 e or “metabotype” of an organism in volume-restricted/mass-limited bio
 specimens. Recent studies will include the discovery of putative markers f
 or early detection of cystic fibrosis in newborn screening programs\, food
 -specific markers for validation of dietary interventions that promote hum
 an health\, as well as risk assessment of smoke-exposure in firefighters c
 onducting training exercises in burn houses.
\nInformation supplémentaire
 Annonce PDF de la conférence
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