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PRODID:https://murmitoyen.com/events/vanille/udem/
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UID:69dd14979e285
DTSTAMP:20260413T120647
DTSTART:20160127T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20160127T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/671462
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence du Professeur Jonathan Sweedler (UIUC)
DESCRIPTION:Titre : New Analytical Tools for the Cell by Cell Chemical Char
 acterization of the Brain.Endroit : Pavillon J-A.-Bombardier\, salle 1035 
 à 11 h.Hôte : Professeur Pierre Thibault.
\nCette conférence sera pron
 oncée par le professeur Jonathan Sweedler du Département de chimie de l'
 University of Illinois at Urbana-Champaign.
\nRésumé : In the postgenomi
 c era\, one expects the suite of chemical players in a brain region to be 
 known and their functions uncovered. However\, many cell-to-cell signaling
  molecules remain poorly characterized and for those that are known\, thei
 r localization and dynamics are oftentimes unknown. A suite of small-scale
  bioanalytical approaches are described that allow the investigation of in
 dividual neurons and small brain regions\; these approaches include capill
 ary scale separations coupled to mass spectrometry and direct mass spectro
 metric-based profiling and mass spectrometry imaging. A key to successful 
 measurement involves optimized tissue and cell sampling protocols. Dependi
 ng on the sample being assayed and metabolites being measured\, we use mec
 hanical isolation\, optical tweezers\, patch pipettes\, dialysis probes an
 d microfluidics\, all of which have advantages for specific sample types. 
 Several applications of single cell microanalysis are highlighted includin
 g the discovery of unusual metabolites to characterizing the peptides in s
 ingle cells. Imaging mass spectrometry and dynamic sampling of the extrace
 llular environment are used for elucidating novel cell to cell signaling m
 olecules in a range of neuronal model systems. Current technology efforts 
 involve extending the depth of metabolome coverage and adapting our approa
 ches to high throughput single cell assays. Our overarching goal is to unc
 over the complex chemical mosaic of the brain and pinpoint key cellular pl
 ayers in physiological and pathological processes.
\nInformation suppléme
 ntaireAnnonce PDF de la conférence
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