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UID:69de12e2d9afe
DTSTAMP:20260414T061146
DTSTART:20150828T110000
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DTEND:20150828T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/626418
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence du Professeur Adrian Schwan (Guelph)
DESCRIPTION:Titre : Sulfenic Acid Anions: Emerging Sulfur Nucleophiles for 
 Synthesis and Stereochemistry.Endroit : Pavillon Roger-Gaudry\, salle G-71
 5 à 11 h.Hôte : Professeur William Lubell.
\nLa conférence sera prononc
 ée (en anglais) par le professeur Adrian Schwan\, du Département de chim
 ie de l'University of Guelph.
\nRésumé : Sulfenic acid anions\, or sulfe
 nates\, which possess the general structure RSO-M+\, are nucleophilic proc
 hiral sulfur species that simultaneously deliver a sulfur and an oxygen to
  an organic substrate. They are central to a bourgeoning area of study tha
 t encompasses organometallic cross couplings and organocatalysis. The Schw
 an group has previously introduced two methods of generating sulfenate ani
 ons and more recently\, has demonstrated for the first time\, their succes
 sful use as prochiral entities upon reaction with homochiral electrophiles
 . The products obtained are chiral β-substituted\, β-amino sulfoxides. O
 ne family of those products\, the 1-alkenyl β-substituted-b-aminoalkyl su
 lfoxides has been subjected to a stereoselective cyclization to create E-3
 \,5-disubstituted thiomorpholine-S-oxides\, which bear a third stereogenic
  centre. By contrast\, cyclization of the sulfone form gives the Z-isomer.
  Novel conditions for Ramberg-Backlund desulfurization of these compounds 
 and hydrogenation completes the enantioselective formation of E- or Z-2\,4
 -disubstituted pyrrolidines\, known constituents of ant venom.
\nInformati
 on supplémentaireAnnonce PDF de la conférence
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