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DTSTART:20150925T113000
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URL:https://murmitoyen.com/events/vanille/udem/detail/624403
LOCATION:Université de Montréal - Pavillon Claire-McNicoll\, 2900\, chemi
 n de la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Séminaire de l'étudiant Juan Carlos Salinas Hernandez (Groupe Han
 essian)
DESCRIPTION:Titre : Synthesis of Constrained Nucleosides for Antisense Tech
 nology.Endroit : Pavillon Claire-McNicoll\, salle Z-315 à 11 h 30.
\nCett
 e conférence sera prononcée (en anglais) par Monsieur Juan Carlos Salina
 s Hernandez\, étudiant au doctorat\, du laboratoire de Stephen Hanessian
 \, professeur au Département de chimie de l'Université de Montréal.
\nR
 ésumé : Antisense technology\, in its basic form\, involves binding of a
  short oligonucleotide sequence to a complementary messenger ribonucleic a
 cid (mRNA)\, which can ultimately result in genetic disease prevention by 
 stopping the production of pathogenic proteins. The underlying principle o
 f this mechanism is that mRNA must remain as a single stranded entity in o
 rder to undergo translation (protein synthesis). Oligonucleotides composed
  of natural nucleic acids are capable of high-affinity binding recognition
  to complementary RNA and DNA sequences\; however\, they rapidly undergo i
 ntracellular digestion through the action of nucleases and are thus unsuit
 able for antisense-based therapeutics. Currently\, there is considerable i
 nterest in the design and synthesis of nucleic acid modifications that mai
 ntain Watson-Crick base pairing properties\, but demonstrate substantial i
 ncreases in nuclease resistance and target (RNA/DNA) binding affinity. The
  main objective of my research is to develop new nucleic acid analogues th
 at can be used as potential antisense agents and in related therapeutic ap
 plications. The targeted nucleoside systems gapmers incorporate structural
  modifications that based on extensive variations of antisense constructs\
 , have proven to be effective in design and synthesis of leading second-ge
 neration nucleic acid monomers.
\nInformation supplémentaireAnnonce PDF d
 u séminaire
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