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UID:69de4d8e20283
DTSTAMP:20260414T102206
DTSTART:20150501T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20150501T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/551013
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Séminaire de l'étudiante Carolyn Ladd (Groupe Charette)
DESCRIPTION:Titre : Palladium-Catalyzed Direct Functionalization of Alpha-C
 yclopropyl Amino Acid-Derivatives.Endroit : Pavillon Roger-Gaudry\, salle 
 G-1015 11 h.Cette conférence sera prononcée (en anglais) par Madame Caro
 lyn Ladd\, étudiante au doctorat\, du laboratoire d'André Charette\, pr
 ofesseur au Département de chimie de l'Université de Montréal.Résumé 
 : In the last ten years\, extensive progress has been made in the area of 
 direct C–H functionalization and the synthetic utility of these reaction
 s has been demonstrated. Cyclopropanes represent an underexplored target f
 or direct functionalization\, despite their known reputation as widely use
 d motifs in current top-selling market pharmaceutical and agrochemicals. W
 ithin this class of compounds\, cyclopropyl amino acids are unique substra
 tes that have found interesting applications in peptidomimetics as the cyc
 lopropyl moiety can impart greater rigidity leading to enhanced biological
  activity. However\, accessing cyclopropyl amino acids and their derivativ
 es remains a challenging synthetic problem. This seminar will describe the
  development of a palladium-catalyzed direct functionalization approach to
 wards accessing cyclopropyl alpha-amino acid derivatives Information suppl
 émentaireAnnonce PDF du séminaire
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