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DTSTAMP:20260415T011121
DTSTART:20141031T113000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20141031T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/475659
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Séminaire de l'étudiante Fatemeh Mohammadpour (Groupe Lubell)
DESCRIPTION:Titre : Synthesis and Evaluation of Azapeptide Modulators of th
 e Prostaglandin F2α Receptor in Pursuit of Inhibitors of Preterm Labour.E
 ndroit : Pavillon Roger-Gaudry\, salle G-1015 à 11 h 30Cette conférence 
 sera prononcée par Madame Fatemeh Mohammadpour\, étudiante au doctorat\,
  du laboratoire de William Lubell\, professeur au Département de chimie 
 de l'Université de Montréal.Résumé : Preterm delivery (J. Biol. Chem. 
 2010\, 285\, 25624-25636) and aza-amino acyl proline analogues (Bourguet\,
  et al. J. Med. Chem. 2011\, 54\, 6085–6097) can reduce prostaglandin-F2
 α-induced myometrial contractions and modulate prostaglandin F2α-induced
  G-protein signaling pathways. My presentation will discuss advances in un
 derstanding the relationship between structure and activity of aza-amino a
 cyl proline modulators. The biological activity of these modulators is con
 tingent on their aaa-residue side chain. Diversity-oriented synthesis meth
 ods to introduce different side chains onto the aza-amino acyl proline mod
 ulators have been pursued featuring alkylation of aza-glycinyl- proline an
 alogs\, as well as copper-catalyzed reactions on aza-propargylglycinyl res
 idues. Finally\, photo-reactive modulators have been pursued to tag the FP
  receptor and identify the allosteric binding site.Information supplément
 aireAnnonce PDF du séminaire
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