BEGIN:VCALENDAR
VERSION:2.0
PRODID:https://murmitoyen.com/events/vanille/udem/
X-WR-TIMEZONE:America/Montreal
BEGIN:VEVENT
UID:69d3b6df8f697
DTSTAMP:20260406T093631
DTSTART:20110428T113000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20110428T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/38644
LOCATION:Université de Montréal - Pavillon Claire-McNicoll\, 2900\, chemi
 n de la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:The blue print of the ribosome building code: Discovering the origi
 n of the ribosomes functional diversity
DESCRIPTION:Conférence du Dr Sherif Abou Elela\, professeur titulaire\, D
 épartement de microbiologie et d'infectiologie à l'Université de Sherbr
 ooke\, Cette conférence sera prononcée en anglais.Résumé In baker’s
  yeast\, ribosome synthesis requires the correct expression of 150 ribosom
 al RNA (rRNA) and 137 ribosomal protein (RP) genes. The majority of RP gen
 es have been shown to be duplicated in this species\, although both the ra
 tional for maintaining these genes-duplications and their functional signi
 ficance remain unclear. It was initially believed that gene duplications p
 ermit adjustment of the RP dose to match that of rRNA synthesis\, thereby 
 ensuring ribosome assembly. However\, in the yeast Saccharomyces cerevisia
 e the majority of the RP paralogs are not equally expressed and the expres
 sion of the RP paralogs is controlled by independent regulatory mechanisms
 \, and in many cases any alteration of the expression ratio of the duplica
 ted genes impaired cell growth under stress. Consistently\, single paralog
  deletion induced distinct defects in pre-rRNA processing. Strikingly\, we
  have shown that changing the ratio of the duplicated RP genes can modulat
 e both the resistance to antibiotics and the response to stress. These obs
 ervations argue against an equal and redundant role for the duplicated gen
 es\, and suggest a new model in which each paralog is individually regulat
 ed and serves a specific function during ribosome biogenesis and protein s
 ynthesis. In this presentation\, we will discuss the basis of ribosomes fu
 nctional diversity and explore possible models for introns function in yea
 st. Conférence présentée par le Département de microbiologie et immun
 ologie de l'Université de Montréal. Crédit photo : site Web du Départe
 ment de microbiologie et immunologie
END:VEVENT
BEGIN:VTIMEZONE
TZID:America/Montreal
X-LIC-LOCATION:America/Montreal
END:VTIMEZONE
END:VCALENDAR