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DTSTART:20140326T110000
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URL:https://murmitoyen.com/events/vanille/udem/detail/354164
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence CCVC avec le Professeur Harald Gröger (Bielefeld)
DESCRIPTION:Titre : Green Chemistry Through Biocatalysis: From Process Deve
 lopment Towards Integration in Chemoenzymatic One-Pot Processes.La confér
 ence sera prononcée en anglais par le professeur Harald Gröger du Dépar
 tement de chimie de l'Université de Bielefeld (Allemagne). Elle est comma
 nditée par le Centre en chimie verte et catalyse (CCVC)Résumé : The re
 search activities of the Gröger group center around the application of en
 zymes as valuable and environmental friendly catalysts in organic syntheti
 c transformations. A particular goal of the highly interdisciplinary resea
 rch projects is the development of organic synthetic processes which fulfi
 l the criteria of high efficiency\, sustainability and scalability. To rea
 lize such processes we focus on (1) the development of efficient biocataly
 tic reactions and technical applications thereof\, (2) the combination of 
 biocatalysis with chemocatalysis in one-pot multi-step syntheses in water\
 , and (3) target driven synthesis based on the use of biocatalysts in synt
 hetic key steps for the production of fine chemicals and pharmaceuticals.I
 n the research area of bioprocess development Gröger and his teams (in in
 dustry until 2006\, at the University of Erlangen-Nürnberg from 2006 to 2
 011 and at Bielefeld University since 2011) developed successfully many ne
 w biocatalytic processes applying\, e.g.\, innovative biocatalyst concepts
 . Within these interdisciplinary projects jointly with collaboration partn
 ers several processes running on industrial scale have been realized. A pa
 rticular highlight is the developed highly efficient asymmetric biocatalyt
 ic reduction and reductive amination technology based on the use of recomb
 inant whole cell catalysts. Both types of processes run at high substrate 
 loading of typically >100 g/L and give the desired products with >99% ee. 
 Recently\, jointly with collaboration partners new biocatalytic processes 
 have been developed using enoate reductases (for C= C-reduction) and L-thr
 eonine aldolases (for aldol reactions). Furthermore various chemoenzymatic
  one-pot multi-step processes in water have been developed by combining 
 “classic” chemical reactions\, metal-catalyzed reactions and organocat
 alytic reactions\, respectively\, with enzymatic transformations\, leading
  to an efficient formation of the desired products with excellent enantios
 electivity. These research achievements underline that such combinations o
 f the two “worlds of catalysis”\, chemocatalysis and biocatalysis\, ar
 e possible\, enabling advantageous synthetic processes\, which avoid solve
 nt-intensive and waste-generating process steps. Furthermore\, we could su
 ccessfully apply biocatalysts in the enantioselective (multi-step) synthes
 is of pharmaceutically relevant molecules. By means of different types of 
 biotransformations as key steps\, novel synthetic approaches towards\, e.g
 .\, non-natural -amino acids\, -amino acid derivatives and specific chiral
  alcohols have been realized.Publications sélectionnées :-  Angew. Chem
 . Int. Ed. 2006\, 45\, 1645-1648.-  Angew. Chem. Int. Ed. 2006\, 45\, 567
 7-5681.-  Angew. Chem. Int. Ed. 2008\, 47\, 9551-9554.-  Angew. Chem. I
 nt. Ed. 2009\, 48\, 9355-9358.-  Angew. Chem. Int. Ed. 2011\, 50\, 2397-2
 400.-  Angew. Chem. Int. Ed. 2011\, 50\, 7944-7947.-  Angew. Chem. Int. 
 Ed. 2013\, 52\, 2359-2363.-  Angew. Chem. Int. Ed. 2013\, 52\, 9323-9326.
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