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DTSTAMP:20260415T220142
DTSTART:20140122T110000
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DTEND:20140122T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/251047
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence de la Professeure Hanadi Sleiman (McGill)
DESCRIPTION:Titre :  Three-Dimensional DNA Structures for Biological and M
 aterials Applications.La conférence sera prononcée par la professeure Ha
 nadi Sleiman du Département de chimie de l'Université McGill. Elle sera 
 donnée en anglais. Résumé : Three-dimensional structures made of DNA h
 old the potential to encapsulate and release drugs\, regulate the assembly
  and activity of proteins\,and organize networks for catalysis and biomole
 cule crystallization.  This talk will describe our research group’s syn
 thetic approaches to 3D-DNA structures\, such as DNA cages and nanotubes.
   These can be accessed with deliberate variation of geometry\, size\, si
 ngle- and double-stranded forms\, permeability and length.  They can be d
 ynamically switched to different internal volumes\, and can be ‘opened
 ’ or closed with specific DNA strands. The size-selective encapsulation 
 of nanoparticles and small molecules within these host structures\, and th
 e release of this cargo when specific DNA strands are added will be shown.
   We will also describe the use of these cages for the anisotropic organi
 zation of transition metals and hydrophobic units\, thus defining new mode
 s of protein-inspired interactions. These compact 3D-DNA structures can tr
 avel across the plasma membrane of a number of mammalian cells and result 
 in efficient gene silencing. The molecules shown here represent a new clas
 s of selective cellular probes and drug delivery tools\, and can assist th
 e development of nucleic acid therapeutic routes. Références sélection
 nées : Science\, 2008\, 321\, 1795\; Nature Chem. 2013\, 5\, 868\; J. Am.
  Chem. Soc. 2013\, 135\, 11283\; ACS Nano 2013\, 7\, 3022\; Chem. Sci. 201
 2\, 3\, 1980\;  J. Am. Chem. Soc. 2012\, 134 14382\; J. Am. Chem. Soc. 20
 12\, 134\, 4280\; J. Am. Chem. Soc. 2012\, 134\, 2888\; J. Am. Chem. Soc. 
 2010\, 132\, 10212\; Nature Chem. 2010\, 2\, 319\; Nature Chem. 2009\, 1\,
  390\; Nature Nanotech. 2009\, 4\, 349\; J. Am. Chem. Soc. 2007\, 129\, 13
 376.  Information supplémentaire
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